tetano
Editor, Senior Moderator
J Korean Med Sci
. 2022 Mar 7;37(9):e70.
doi: 10.3346/jkms.2022.37.e70.
Booster BNT162b2 COVID-19 Vaccination Increases Neutralizing Antibody Titers Against the SARS-CoV-2 Omicron Variant in Both Young and Elderly Adults
Jihye Um[SUP] #[/SUP][SUP] 1 [/SUP], Youn Young Choi[SUP] #[/SUP][SUP] 1 2 [/SUP], Gayeon Kim[SUP] 3 [/SUP], Min-Kyung Kim[SUP] 3 [/SUP], Kyung-Shin Lee[SUP] 1 [/SUP], Ho Kyung Sung[SUP] 1 [/SUP], Byung Chul Kim[SUP] 4 [/SUP], Yoo-Kyoung Lee[SUP] 4 [/SUP], Hee-Chang Jang[SUP] 4 [/SUP], Ji Hwan Bang[SUP] 5 [/SUP], Ki-Hyun Chung[SUP] 2 [/SUP], Myoung-Don Oh[SUP] 6 [/SUP], Jun-Sun Park[SUP] 7 [/SUP], Jaehyun Jeon[SUP] 1 8 [/SUP]
Affiliations
Abstract
Concerns about the effectiveness of current vaccines against the rapidly spreading severe acute respiratory syndrome-coronavirus-2 omicron (B.1.1.529) variant are increasing. This study aimed to assess neutralizing antibody activity against the wild-type (BetaCoV/Korea/KCDC03/2020), delta, and omicron variants after full primary and booster vaccinations with BNT162b2. A plaque reduction neutralization test was employed to determine 50% neutralizing dilution (ND[SUB]50[/SUB]) titers in serum samples. ND[SUB]50[/SUB] titers against the omicron variant (median [interquartile range], 5.3 [< 5.0-12.7]) after full primary vaccination were lower than those against the wild-type (144.8 [44.7-294.0]) and delta (24.3 [14.3-81.1]) variants. Furthermore, 19/30 participants (63.3%) displayed lower ND[SUB]50[/SUB] titers than the detection threshold (< 10.0) against omicron after full primary vaccination. However, the booster vaccine significantly increased ND[SUB]50[/SUB] titers against BetaCoV/Korea/KCDC03/2020, delta, and omicron, although titers against omicron remained lower than those against the other variants (P < 0.001). Our study suggests that booster vaccination with BNT162b2 significantly increases humoral immunity against the omicron variant.
Keywords: Antibodies; COVID-19 Vaccine; Immunity; Omicron Variant; Republic of Korea.
. 2022 Mar 7;37(9):e70.
doi: 10.3346/jkms.2022.37.e70.
Booster BNT162b2 COVID-19 Vaccination Increases Neutralizing Antibody Titers Against the SARS-CoV-2 Omicron Variant in Both Young and Elderly Adults
Jihye Um[SUP] #[/SUP][SUP] 1 [/SUP], Youn Young Choi[SUP] #[/SUP][SUP] 1 2 [/SUP], Gayeon Kim[SUP] 3 [/SUP], Min-Kyung Kim[SUP] 3 [/SUP], Kyung-Shin Lee[SUP] 1 [/SUP], Ho Kyung Sung[SUP] 1 [/SUP], Byung Chul Kim[SUP] 4 [/SUP], Yoo-Kyoung Lee[SUP] 4 [/SUP], Hee-Chang Jang[SUP] 4 [/SUP], Ji Hwan Bang[SUP] 5 [/SUP], Ki-Hyun Chung[SUP] 2 [/SUP], Myoung-Don Oh[SUP] 6 [/SUP], Jun-Sun Park[SUP] 7 [/SUP], Jaehyun Jeon[SUP] 1 8 [/SUP]
Affiliations
- PMID: 35257525
- DOI: 10.3346/jkms.2022.37.e70
Abstract
Concerns about the effectiveness of current vaccines against the rapidly spreading severe acute respiratory syndrome-coronavirus-2 omicron (B.1.1.529) variant are increasing. This study aimed to assess neutralizing antibody activity against the wild-type (BetaCoV/Korea/KCDC03/2020), delta, and omicron variants after full primary and booster vaccinations with BNT162b2. A plaque reduction neutralization test was employed to determine 50% neutralizing dilution (ND[SUB]50[/SUB]) titers in serum samples. ND[SUB]50[/SUB] titers against the omicron variant (median [interquartile range], 5.3 [< 5.0-12.7]) after full primary vaccination were lower than those against the wild-type (144.8 [44.7-294.0]) and delta (24.3 [14.3-81.1]) variants. Furthermore, 19/30 participants (63.3%) displayed lower ND[SUB]50[/SUB] titers than the detection threshold (< 10.0) against omicron after full primary vaccination. However, the booster vaccine significantly increased ND[SUB]50[/SUB] titers against BetaCoV/Korea/KCDC03/2020, delta, and omicron, although titers against omicron remained lower than those against the other variants (P < 0.001). Our study suggests that booster vaccination with BNT162b2 significantly increases humoral immunity against the omicron variant.
Keywords: Antibodies; COVID-19 Vaccine; Immunity; Omicron Variant; Republic of Korea.