tetano
Editor, Senior Moderator
J Infect
. 2024 Nov 1:106338.
doi: 10.1016/j.jinf.2024.106338. Online ahead of print. Near Real-Time Severe Acute Respiratory Illness Surveillance Characterising Influenza and COVID-19 Epidemiology in Hospitalised Adults, 2021-22
Antonia Ho[SUP] 1 [/SUP], Neil McInnes[SUP] 2 [/SUP], Andrew Blunsum[SUP] 2 [/SUP], Joanna Quinn[SUP] 2 [/SUP], Daniel Lynagh[SUP] 3 [/SUP], Michael E Murphy[SUP] 4 [/SUP], Rory Gunson[SUP] 5 [/SUP], Alisdair MacConnachie[SUP] 2 [/SUP], David J Lowe[SUP] 6 [/SUP]
Affiliations
Objectives: We report the findings of a novel enhanced syndromic surveillance which characterised influenza- and SARS-CoV-2-associated severe acute respiratory illness (SARI) in the 2021/2022 winter season.
Methods: Prospective cohort study of adults admitted to the Queen Elizabeth University Hospital, Glasgow, with a severe acute respiratory illness. Patient demographics, clinical history, admission details, and outcome were recorded. Data were available to Public Health Scotland (PHS) and clinicians weekly.
Results: Between November 2021 and May 2022, 1,063 hospitalised SARI episodes in 1,037 adult patients were identified. Median age was 72.0 years and 44.5% were male. Most (82.6%) SARI cases had >1 co-morbidity; chronic lung disease (50.0%) and malignancy (22.5%) were the most frequently reported. Overall, 229 (22%) and 33 (3%) SARI episodes were SARS-CoV-2 and influenza A PCR positive, respectively. 74.7%, 6.5% and 43.0% SARI episodes received antibiotics, antivirals, and steroids, respectively (54.5, 11.0 and 51.3% among COVID-19 patients). 1.1% required mechanical ventilation and 7.8% died. Male sex, multimorbidity, frailty, respiratory rate >30, low GCS and chest X-ray consolidation were predictive of in-hospital mortality.
Conclusion: Near real-time hospitalised SARI syndromic surveillance characterised the evolving clinical epidemiology of SARS-CoV-2 and influenza, high antimicrobial use, and predictors of inpatient mortality among hospitalised SARI patients.
Keywords: COVID-19; SARS-CoV-2; influenza; severe acute respiratory illness; syndromic surveillance.
. 2024 Nov 1:106338.
doi: 10.1016/j.jinf.2024.106338. Online ahead of print. Near Real-Time Severe Acute Respiratory Illness Surveillance Characterising Influenza and COVID-19 Epidemiology in Hospitalised Adults, 2021-22
Antonia Ho[SUP] 1 [/SUP], Neil McInnes[SUP] 2 [/SUP], Andrew Blunsum[SUP] 2 [/SUP], Joanna Quinn[SUP] 2 [/SUP], Daniel Lynagh[SUP] 3 [/SUP], Michael E Murphy[SUP] 4 [/SUP], Rory Gunson[SUP] 5 [/SUP], Alisdair MacConnachie[SUP] 2 [/SUP], David J Lowe[SUP] 6 [/SUP]
Affiliations
- PMID: 39489182
- DOI: 10.1016/j.jinf.2024.106338
Objectives: We report the findings of a novel enhanced syndromic surveillance which characterised influenza- and SARS-CoV-2-associated severe acute respiratory illness (SARI) in the 2021/2022 winter season.
Methods: Prospective cohort study of adults admitted to the Queen Elizabeth University Hospital, Glasgow, with a severe acute respiratory illness. Patient demographics, clinical history, admission details, and outcome were recorded. Data were available to Public Health Scotland (PHS) and clinicians weekly.
Results: Between November 2021 and May 2022, 1,063 hospitalised SARI episodes in 1,037 adult patients were identified. Median age was 72.0 years and 44.5% were male. Most (82.6%) SARI cases had >1 co-morbidity; chronic lung disease (50.0%) and malignancy (22.5%) were the most frequently reported. Overall, 229 (22%) and 33 (3%) SARI episodes were SARS-CoV-2 and influenza A PCR positive, respectively. 74.7%, 6.5% and 43.0% SARI episodes received antibiotics, antivirals, and steroids, respectively (54.5, 11.0 and 51.3% among COVID-19 patients). 1.1% required mechanical ventilation and 7.8% died. Male sex, multimorbidity, frailty, respiratory rate >30, low GCS and chest X-ray consolidation were predictive of in-hospital mortality.
Conclusion: Near real-time hospitalised SARI syndromic surveillance characterised the evolving clinical epidemiology of SARS-CoV-2 and influenza, high antimicrobial use, and predictors of inpatient mortality among hospitalised SARI patients.
Keywords: COVID-19; SARS-CoV-2; influenza; severe acute respiratory illness; syndromic surveillance.