tetano
Editor, Senior Moderator
J Infect Dis
. 2022 Sep 2;jiac358.
doi: 10.1093/infdis/jiac358. Online ahead of print.
Omicron SARS-CoV-2 Neutralization by Immunoglobulin Preparations Manufactured from Plasma Collected in the US and Europe
Maria R Farcet[SUP] 1 [/SUP], Michael Karbiener[SUP] 1 [/SUP], Simone Knotzer[SUP] 1 [/SUP], Julia Schwaiger[SUP] 1 [/SUP], Thomas R Kreil[SUP] 1 [/SUP]
Affiliations
Abstract
After >2 years of the COVID-19 pandemic, immunoglobulins (IG) contain highly potent SARS-CoV-2 neutralizing antibodies, based on the large proportion of US plasma donors who have gone through COVID-19 or vaccination against the virus. Neutralization of Omicron SARS-CoV-2 by antibodies generated after non-Omicron infection or vaccination has been lower though, raising concerns about the potency of IG against this new virus variant. Also, as plasma collected in the US remains the main source of IG, the neutralization of SARS-CoV-2 for plasma collected elsewhere has been less well studied. Here, we confirm Omicron neutralization by US as well as EU plasma-derived IG lots.
Keywords: COVID-19; Omicron; Primary immunodeficiency; SARS coronavirus 2 antibody potency; SARS-CoV-2; Secondary immunodeficiency; immunoglobulin; intravenous immune globulin; neutralizing antibodies; prophylaxis.
. 2022 Sep 2;jiac358.
doi: 10.1093/infdis/jiac358. Online ahead of print.
Omicron SARS-CoV-2 Neutralization by Immunoglobulin Preparations Manufactured from Plasma Collected in the US and Europe
Maria R Farcet[SUP] 1 [/SUP], Michael Karbiener[SUP] 1 [/SUP], Simone Knotzer[SUP] 1 [/SUP], Julia Schwaiger[SUP] 1 [/SUP], Thomas R Kreil[SUP] 1 [/SUP]
Affiliations
- PMID: 36052810
- DOI: 10.1093/infdis/jiac358
Abstract
After >2 years of the COVID-19 pandemic, immunoglobulins (IG) contain highly potent SARS-CoV-2 neutralizing antibodies, based on the large proportion of US plasma donors who have gone through COVID-19 or vaccination against the virus. Neutralization of Omicron SARS-CoV-2 by antibodies generated after non-Omicron infection or vaccination has been lower though, raising concerns about the potency of IG against this new virus variant. Also, as plasma collected in the US remains the main source of IG, the neutralization of SARS-CoV-2 for plasma collected elsewhere has been less well studied. Here, we confirm Omicron neutralization by US as well as EU plasma-derived IG lots.
Keywords: COVID-19; Omicron; Primary immunodeficiency; SARS coronavirus 2 antibody potency; SARS-CoV-2; Secondary immunodeficiency; immunoglobulin; intravenous immune globulin; neutralizing antibodies; prophylaxis.