tetano
Editor, Senior Moderator
J Infect Dis
. 2022 Mar 10;jiac092.
doi: 10.1093/infdis/jiac092. Online ahead of print.
Neutralizing Activities against the Omicron Variant after a Heterologous Booster in Healthy Adults Receiving Two Doses of CoronaVac Vaccination
Suvichada Assawakosri[SUP] 1 2 [/SUP], Sitthichai Kanokudom[SUP] 1 2 [/SUP], Nungruthai Suntronwong[SUP] 1 [/SUP], Chompoonut Auphimai[SUP] 1 [/SUP], Pornjarim Nilyanimit[SUP] 1 [/SUP], Preeyaporn Vichaiwattana[SUP] 1 [/SUP], Thanunrat Thongmee[SUP] 1 [/SUP], Thaneeya Duangchinda[SUP] 3 [/SUP], Warangkana Chantima[SUP] 4 5 [/SUP], Pattarakul Pakchotanon[SUP] 3 [/SUP], Donchida Srimuan[SUP] 1 [/SUP], Thaksaporn Thatsanatorn[SUP] 1 [/SUP], Sirapa Klinfueng[SUP] 1 [/SUP], Ritthideach Yorsang[SUP] 1 [/SUP], Natthinee Sudhinaraset[SUP] 1 [/SUP], Nasamon Wanlapakorn[SUP] 1 [/SUP], Juthathip Mongkolsapaya[SUP] 6 7 [/SUP], Sittisak Honsawek[SUP] 2 [/SUP], Yong Poovorawan[SUP] 1 8 [/SUP]
Affiliations
Abstract
Background: The use of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac) against SARS-CoV-2 is implemented worldwide. However, waning immunity and breakthrough infections have been observed. Therefore, we hypothesized that the heterologous booster might improve the protection against the delta and omicron variants.
Methods: A total of 224 individuals who completed the two-dose CoronaVac for six months were included. We studied reactogenicity and immunogenicity following a heterologous booster with the inactivated vaccine (BBIBP), the viral vector vaccine (AZD1222), and the mRNA vaccine (both BNT162B2 and mRNA-1273). We also determined immunogenicity at 3- and 6-months boosting intervals.
Results: The solicited adverse events (AEs) were mild to moderate and well-tolerated. Total RBD immunoglobulin (Ig), anti-RBD IgG, focus reduction neutralization test (FRNT50) against delta and omicron variants, and T-cell response were highest in the mRNA-1273 group followed by the BNT162b2, AZD1222 and BBIBP groups, respectively. We also witnessed a higher total Ig anti-RBD in the long-interval than in the short-interval groups.
Conclusions: All four booster vaccines significantly increased binding and neutralizing antibody (NAbs) in individuals immunized with two doses of CoronaVac. The present evidence may benefit vaccine strategies to thwart variants of concern, including the omicron variant.
Keywords: AZD1222; BNT162b2; COVID-19; T cells; Third dose; heterologous booster; mRNA-1273; neutralizing antibody; omicron.
. 2022 Mar 10;jiac092.
doi: 10.1093/infdis/jiac092. Online ahead of print.
Neutralizing Activities against the Omicron Variant after a Heterologous Booster in Healthy Adults Receiving Two Doses of CoronaVac Vaccination
Suvichada Assawakosri[SUP] 1 2 [/SUP], Sitthichai Kanokudom[SUP] 1 2 [/SUP], Nungruthai Suntronwong[SUP] 1 [/SUP], Chompoonut Auphimai[SUP] 1 [/SUP], Pornjarim Nilyanimit[SUP] 1 [/SUP], Preeyaporn Vichaiwattana[SUP] 1 [/SUP], Thanunrat Thongmee[SUP] 1 [/SUP], Thaneeya Duangchinda[SUP] 3 [/SUP], Warangkana Chantima[SUP] 4 5 [/SUP], Pattarakul Pakchotanon[SUP] 3 [/SUP], Donchida Srimuan[SUP] 1 [/SUP], Thaksaporn Thatsanatorn[SUP] 1 [/SUP], Sirapa Klinfueng[SUP] 1 [/SUP], Ritthideach Yorsang[SUP] 1 [/SUP], Natthinee Sudhinaraset[SUP] 1 [/SUP], Nasamon Wanlapakorn[SUP] 1 [/SUP], Juthathip Mongkolsapaya[SUP] 6 7 [/SUP], Sittisak Honsawek[SUP] 2 [/SUP], Yong Poovorawan[SUP] 1 8 [/SUP]
Affiliations
- PMID: 35267040
- DOI: 10.1093/infdis/jiac092
Abstract
Background: The use of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac) against SARS-CoV-2 is implemented worldwide. However, waning immunity and breakthrough infections have been observed. Therefore, we hypothesized that the heterologous booster might improve the protection against the delta and omicron variants.
Methods: A total of 224 individuals who completed the two-dose CoronaVac for six months were included. We studied reactogenicity and immunogenicity following a heterologous booster with the inactivated vaccine (BBIBP), the viral vector vaccine (AZD1222), and the mRNA vaccine (both BNT162B2 and mRNA-1273). We also determined immunogenicity at 3- and 6-months boosting intervals.
Results: The solicited adverse events (AEs) were mild to moderate and well-tolerated. Total RBD immunoglobulin (Ig), anti-RBD IgG, focus reduction neutralization test (FRNT50) against delta and omicron variants, and T-cell response were highest in the mRNA-1273 group followed by the BNT162b2, AZD1222 and BBIBP groups, respectively. We also witnessed a higher total Ig anti-RBD in the long-interval than in the short-interval groups.
Conclusions: All four booster vaccines significantly increased binding and neutralizing antibody (NAbs) in individuals immunized with two doses of CoronaVac. The present evidence may benefit vaccine strategies to thwart variants of concern, including the omicron variant.
Keywords: AZD1222; BNT162b2; COVID-19; T cells; Third dose; heterologous booster; mRNA-1273; neutralizing antibody; omicron.