tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Aug 11;jiaa493.
doi: 10.1093/infdis/jiaa493. Online ahead of print.
Influenza vaccination protects against hospitalization outcomes among older patients with cardiovascular or respiratory diseases
Yuanjie Pang[SUP] 1 [/SUP], Qi Wang[SUP] 2 3 [/SUP], Min Lv[SUP] 4 [/SUP], Mengke Yu[SUP] 3 [/SUP], Ming Lu[SUP] 5 [/SUP], Jiang Wu[SUP] 4 [/SUP], Zheng Xie[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Influenza vaccination has been suggested to protect against mortality and recurrent events among patients with cardiovascular disease or chronic obstructive respiratory disease, but there is limited evidence in older adults, who have higher risks of influenza-associated hospitalization and mortality.
Methods: Patients aged ≥60 years hospitalized for cardiovascular or respiratory diseases from the Beijing Urban Employee Basic Medical Insurance database during three influenza seasons (2013/2014-2015/2016) were pooled to estimate the effectiveness of influenza vaccination on hospitalization outcomes. Vaccination status was ascertained through cross-referencing the Beijing Elderly Influenza Vaccination database. The summer months (June-August) were used as a reference period to adjust for unmeasured confounders during influenza seasons.
Results: After adjusting for both measured and unmeasured confounders, influenza vaccination was associated with lower risks of in-hospital deaths among patients hospitalized for cardiovascular (odds ratio [OR] 0.85 [0.68-1.06]) or respiratory diseases (0.66 [0.54-0.82]). Influenza vaccination was associated with a lower risk of re-admission among patients with cardiovascular (OR 0.81 [0.69-0.95]) but not respiratory diseases (1.12 [0.92-1.35]). Influenza vaccination was also associated with lower direct medical costs, but not with length of stay.
Conclusions: Influenza vaccination protected against hospitalization outcomes among older adults with cardiovascular or respiratory diseases.
Keywords: Influenza vaccination; cardiovascular disease; hospitalization; older adults; respiratory disease.
. 2020 Aug 11;jiaa493.
doi: 10.1093/infdis/jiaa493. Online ahead of print.
Influenza vaccination protects against hospitalization outcomes among older patients with cardiovascular or respiratory diseases
Yuanjie Pang[SUP] 1 [/SUP], Qi Wang[SUP] 2 3 [/SUP], Min Lv[SUP] 4 [/SUP], Mengke Yu[SUP] 3 [/SUP], Ming Lu[SUP] 5 [/SUP], Jiang Wu[SUP] 4 [/SUP], Zheng Xie[SUP] 3 [/SUP]
Affiliations
- PMID: 32779725
- DOI: 10.1093/infdis/jiaa493
Abstract
Background: Influenza vaccination has been suggested to protect against mortality and recurrent events among patients with cardiovascular disease or chronic obstructive respiratory disease, but there is limited evidence in older adults, who have higher risks of influenza-associated hospitalization and mortality.
Methods: Patients aged ≥60 years hospitalized for cardiovascular or respiratory diseases from the Beijing Urban Employee Basic Medical Insurance database during three influenza seasons (2013/2014-2015/2016) were pooled to estimate the effectiveness of influenza vaccination on hospitalization outcomes. Vaccination status was ascertained through cross-referencing the Beijing Elderly Influenza Vaccination database. The summer months (June-August) were used as a reference period to adjust for unmeasured confounders during influenza seasons.
Results: After adjusting for both measured and unmeasured confounders, influenza vaccination was associated with lower risks of in-hospital deaths among patients hospitalized for cardiovascular (odds ratio [OR] 0.85 [0.68-1.06]) or respiratory diseases (0.66 [0.54-0.82]). Influenza vaccination was associated with a lower risk of re-admission among patients with cardiovascular (OR 0.81 [0.69-0.95]) but not respiratory diseases (1.12 [0.92-1.35]). Influenza vaccination was also associated with lower direct medical costs, but not with length of stay.
Conclusions: Influenza vaccination protected against hospitalization outcomes among older adults with cardiovascular or respiratory diseases.
Keywords: Influenza vaccination; cardiovascular disease; hospitalization; older adults; respiratory disease.