tetano
Editor, Senior Moderator
J Infect Dis
. 2024 Jul 25;230(1):e30-e33.
doi: 10.1093/infdis/jiad603. Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Zahra R Tehrani[SUP] 1 [/SUP], Parham Habibzadeh[SUP] 1 [/SUP], Robin Flinko[SUP] 1 [/SUP], Hegang Chen[SUP] 2 [/SUP], Abdolrahim Abbasi[SUP] 1 [/SUP], Jean A Yared[SUP] 3 [/SUP], Stanca M Ciupe[SUP] 4 [/SUP], George K Lewis[SUP] 1 [/SUP], Mohammad M Sajadi[SUP] 1 5 [/SUP]
Affiliations
Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized the antibody response using bone marrow aspiration and plasma samples. We noted deficient generation of spike-specific LLPCs in the bone marrow after severe acute respiratory syndrome coronavirus 2 infection. Furthermore, while the regression model explained 98% of the observed variance in anti-tetanus immunoglobulin G levels based on LLPC enzyme-linked immunospot assay, we were unable to fit the same model with anti-spike antibodies, again pointing to the lack of LLPC contribution to circulating anti-spike antibodies.
Keywords: COVID-19; SARS-CoV-2; humoral immunity; immunological memory; plasma cells.
. 2024 Jul 25;230(1):e30-e33.
doi: 10.1093/infdis/jiad603. Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Zahra R Tehrani[SUP] 1 [/SUP], Parham Habibzadeh[SUP] 1 [/SUP], Robin Flinko[SUP] 1 [/SUP], Hegang Chen[SUP] 2 [/SUP], Abdolrahim Abbasi[SUP] 1 [/SUP], Jean A Yared[SUP] 3 [/SUP], Stanca M Ciupe[SUP] 4 [/SUP], George K Lewis[SUP] 1 [/SUP], Mohammad M Sajadi[SUP] 1 5 [/SUP]
Affiliations
- PMID: 39052732
- DOI: 10.1093/infdis/jiad603
Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized the antibody response using bone marrow aspiration and plasma samples. We noted deficient generation of spike-specific LLPCs in the bone marrow after severe acute respiratory syndrome coronavirus 2 infection. Furthermore, while the regression model explained 98% of the observed variance in anti-tetanus immunoglobulin G levels based on LLPC enzyme-linked immunospot assay, we were unable to fit the same model with anti-spike antibodies, again pointing to the lack of LLPC contribution to circulating anti-spike antibodies.
Keywords: COVID-19; SARS-CoV-2; humoral immunity; immunological memory; plasma cells.