tetano
Editor, Senior Moderator
J Infect Dis
. 2022 Apr 5;jiac117.
doi: 10.1093/infdis/jiac117. Online ahead of print.
Biphasic waning of hemagglutination inhibition antibody titers after influenza vaccination in children
Weijia Xiong[SUP] 1 [/SUP], Tim K Tsang[SUP] 1 2 [/SUP], Ranawaka A P M Perera[SUP] 1 [/SUP], Nancy H L Leung[SUP] 1 2 [/SUP], Vicky J Fang[SUP] 1 [/SUP], Ian G Barr[SUP] 3 [/SUP], J S Malik Peiris[SUP] 1 2 4 [/SUP], Benjamin J Cowling[SUP] 1 2 [/SUP]
Affiliations
Abstract
We explored the potential for a biphasic pattern in waning of antibody titers after influenza vaccination. We collected blood samples in a randomized controlled trial of influenza vaccination in children, and tested them with hemagglutination inhibition (HAI) assays for influenza A(H3N2) and influenza B/Victoria lineage. Using piecewise log-linear mixed-effect models, we found evidence for a faster initial waning of antibody titers for the first 1-2 years after vaccination and then slower longer-term declines. Children with higher post-vaccination titers had faster antibody decay.
Keywords: antibody; children; influenza; vaccine; waning.
. 2022 Apr 5;jiac117.
doi: 10.1093/infdis/jiac117. Online ahead of print.
Biphasic waning of hemagglutination inhibition antibody titers after influenza vaccination in children
Weijia Xiong[SUP] 1 [/SUP], Tim K Tsang[SUP] 1 2 [/SUP], Ranawaka A P M Perera[SUP] 1 [/SUP], Nancy H L Leung[SUP] 1 2 [/SUP], Vicky J Fang[SUP] 1 [/SUP], Ian G Barr[SUP] 3 [/SUP], J S Malik Peiris[SUP] 1 2 4 [/SUP], Benjamin J Cowling[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35380689
- DOI: 10.1093/infdis/jiac117
Abstract
We explored the potential for a biphasic pattern in waning of antibody titers after influenza vaccination. We collected blood samples in a randomized controlled trial of influenza vaccination in children, and tested them with hemagglutination inhibition (HAI) assays for influenza A(H3N2) and influenza B/Victoria lineage. Using piecewise log-linear mixed-effect models, we found evidence for a faster initial waning of antibody titers for the first 1-2 years after vaccination and then slower longer-term declines. Children with higher post-vaccination titers had faster antibody decay.
Keywords: antibody; children; influenza; vaccine; waning.