tetano
Editor, Senior Moderator
J Infect Dis
. 2022 Apr 18;jiac119.
doi: 10.1093/infdis/jiac119. Online ahead of print.
B cell responses in hospitalized SARS-CoV-2-infected children with and without Multisystem Inflammatory Syndrome
Nadine Peart Akindele[SUP] 1 2 [/SUP], Lisa Pieterse[SUP] 2 [/SUP], San Suwanmanee[SUP] 2 [/SUP], Diane E Griffin[SUP] 2 [/SUP]
Affiliations
Abstract
Multisystem inflammatory syndrome in children (MIS-C) can complicate infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but differences in the immune responses during MIS-C compared to coronavirus disease 2019 (COVID-19) are poorly understood. We longitudinally compared the amounts and avidity of plasma anti-nucleocapsid (N) and spike (S) antibodies, phenotypes of B cells and numbers of virus-specific antibody-secreting cells in circulation of children hospitalized with COVID-19 (N=10) and with MIS-C (N=12). N-specific IgG was higher early after presentation for MIS-C than COVID-19 patients and avidity of N- and S-specific IgG at presentation did not mature further during follow up as it did for COVID-19. Both groups had waning proportions of B cells in circulation and decreasing but sustained production of virus-specific antibody-secreting cells for months. Overall, B cell responses were similar, but those with MIS-C demonstrated a more mature antibody response at presentation, suggesting a postinfectious entity compared to COVID-19.
Keywords: COVID-19; antibody avidity; antibody-secreting cells; antiviral antibody; flow cytometry.
. 2022 Apr 18;jiac119.
doi: 10.1093/infdis/jiac119. Online ahead of print.
B cell responses in hospitalized SARS-CoV-2-infected children with and without Multisystem Inflammatory Syndrome
Nadine Peart Akindele[SUP] 1 2 [/SUP], Lisa Pieterse[SUP] 2 [/SUP], San Suwanmanee[SUP] 2 [/SUP], Diane E Griffin[SUP] 2 [/SUP]
Affiliations
- PMID: 35436340
- DOI: 10.1093/infdis/jiac119
Abstract
Multisystem inflammatory syndrome in children (MIS-C) can complicate infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but differences in the immune responses during MIS-C compared to coronavirus disease 2019 (COVID-19) are poorly understood. We longitudinally compared the amounts and avidity of plasma anti-nucleocapsid (N) and spike (S) antibodies, phenotypes of B cells and numbers of virus-specific antibody-secreting cells in circulation of children hospitalized with COVID-19 (N=10) and with MIS-C (N=12). N-specific IgG was higher early after presentation for MIS-C than COVID-19 patients and avidity of N- and S-specific IgG at presentation did not mature further during follow up as it did for COVID-19. Both groups had waning proportions of B cells in circulation and decreasing but sustained production of virus-specific antibody-secreting cells for months. Overall, B cell responses were similar, but those with MIS-C demonstrated a more mature antibody response at presentation, suggesting a postinfectious entity compared to COVID-19.
Keywords: COVID-19; antibody avidity; antibody-secreting cells; antiviral antibody; flow cytometry.