tetano
Editor, Senior Moderator
J Immunol Res
. 2021 May 17;2021:5531220.
doi: 10.1155/2021/5531220. eCollection 2021.
Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
Chaiyaporn Kuwentrai[SUP] 1 [/SUP], Jinming Yu[SUP] 2 [/SUP], Bao-Zhong Zhang[SUP] 3 [/SUP], Ye-Fan Hu[SUP] 1 4 [/SUP], Ying Dou[SUP] 1 [/SUP], Hua-Rui Gong[SUP] 1 [/SUP], Jian-Dong Huang[SUP] 1 3 [/SUP], Chenjie Xu[SUP] 2 [/SUP]
Affiliations
Abstract
The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.
. 2021 May 17;2021:5531220.
doi: 10.1155/2021/5531220. eCollection 2021.
Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
Chaiyaporn Kuwentrai[SUP] 1 [/SUP], Jinming Yu[SUP] 2 [/SUP], Bao-Zhong Zhang[SUP] 3 [/SUP], Ye-Fan Hu[SUP] 1 4 [/SUP], Ying Dou[SUP] 1 [/SUP], Hua-Rui Gong[SUP] 1 [/SUP], Jian-Dong Huang[SUP] 1 3 [/SUP], Chenjie Xu[SUP] 2 [/SUP]
Affiliations
- PMID: 34056008
- PMCID: PMC8130907
- DOI: 10.1155/2021/5531220
Abstract
The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.