tetano
Editor, Senior Moderator
J Gerontol A Biol Sci Med Sci. 2020 Apr 11. pii: glaa089. doi: 10.1093/gerona/glaa089. [Epub ahead of print]
Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study.
Chen T[SUP]1[/SUP], Dai Z[SUP]2[/SUP], Mo P[SUP]1[/SUP], Li X[SUP]3[/SUP], Ma Z[SUP]1[/SUP], Song S[SUP]1[/SUP], Chen X[SUP]1[/SUP], Luo M[SUP]1[/SUP], Liang K[SUP]1[/SUP], Gao S[SUP]1[/SUP], Zhang Y[SUP]1[/SUP], Deng L[SUP]1[/SUP], Xiong Y[SUP]1[/SUP].
Author information
Abstract
BACKGROUND:
In December 2019, the coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China and the world. In this study, we aimed to describe the clinical course and outcomes of older patients with COVID-19.
METHODS:
This is a retrospective investigation of hospitalized older patients with confirmed COVID-19 at Zhongnan Hospital of Wuhan University from January 1, 2020, to February 10, 2020.
RESULTS:
In total, 203 patients were diagnosed with COVID-19, with a median age of 54 years (interquartile range, 41-68; range, 20-91 years). Men accounted for 108 (53.2%) of the cases, and 55 patients (27.1%) were >65 years of age. Among patients who were 65 years and older, the mortality rate was 34.5% (19/55), which was significantly higher than that of younger patients at 4.7% (7/148). Common symptoms of older patients with COVID-19 included fever (94.5%; n=52), dry cough (69.1%; n=38), and chest distress (63.6%; n=35). Compared with young patients, older patients had more laboratory abnormalities and comorbidities. Through a multivariate analysis of the causes of death in older patients, we found that males, comorbidities, time from disease onset to hospitalization, abnormal kidney function, and elevated procalcitonin levels were all significantly associated with death.
CONCLUSIONS:
In the recent outbreak of COVID-19, our local hospital in Wuhan found that patients aged 65 and older had greater initial comorbidities, more severe symptoms, and were more likely to experience multi-organ involvement and death, as compared with younger patients.
? The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
KEYWORDS:
COVID-19; SARS-CoV-2; Wuhan; clinical characteristics; coronavirus; older patients
PMID:32279081DOI:10.1093/gerona/glaa089
Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study.
Chen T[SUP]1[/SUP], Dai Z[SUP]2[/SUP], Mo P[SUP]1[/SUP], Li X[SUP]3[/SUP], Ma Z[SUP]1[/SUP], Song S[SUP]1[/SUP], Chen X[SUP]1[/SUP], Luo M[SUP]1[/SUP], Liang K[SUP]1[/SUP], Gao S[SUP]1[/SUP], Zhang Y[SUP]1[/SUP], Deng L[SUP]1[/SUP], Xiong Y[SUP]1[/SUP].
Author information
Abstract
BACKGROUND:
In December 2019, the coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China and the world. In this study, we aimed to describe the clinical course and outcomes of older patients with COVID-19.
METHODS:
This is a retrospective investigation of hospitalized older patients with confirmed COVID-19 at Zhongnan Hospital of Wuhan University from January 1, 2020, to February 10, 2020.
RESULTS:
In total, 203 patients were diagnosed with COVID-19, with a median age of 54 years (interquartile range, 41-68; range, 20-91 years). Men accounted for 108 (53.2%) of the cases, and 55 patients (27.1%) were >65 years of age. Among patients who were 65 years and older, the mortality rate was 34.5% (19/55), which was significantly higher than that of younger patients at 4.7% (7/148). Common symptoms of older patients with COVID-19 included fever (94.5%; n=52), dry cough (69.1%; n=38), and chest distress (63.6%; n=35). Compared with young patients, older patients had more laboratory abnormalities and comorbidities. Through a multivariate analysis of the causes of death in older patients, we found that males, comorbidities, time from disease onset to hospitalization, abnormal kidney function, and elevated procalcitonin levels were all significantly associated with death.
CONCLUSIONS:
In the recent outbreak of COVID-19, our local hospital in Wuhan found that patients aged 65 and older had greater initial comorbidities, more severe symptoms, and were more likely to experience multi-organ involvement and death, as compared with younger patients.
? The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
KEYWORDS:
COVID-19; SARS-CoV-2; Wuhan; clinical characteristics; coronavirus; older patients
PMID:32279081DOI:10.1093/gerona/glaa089