tetano
Editor, Senior Moderator
J Gen Intern Med
. 2020 Aug 19.
doi: 10.1007/s11606-020-06120-6. Online ahead of print.
Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization for COVID-19
Sulaiman S Somani[SUP] 1 2 [/SUP], Felix Richter[SUP] 1 2 [/SUP], Valentin Fuster[SUP] 2 3 [/SUP], Jessica K De Freitas[SUP] 1 2 [/SUP], Nidhi Naik[SUP] 1 2 [/SUP], Keith Sigel[SUP] 2 4 [/SUP], Mount Sinai COVID Informatics Center; Erwin P Bottinger[SUP] 1 2 [/SUP], Matthew A Levin[SUP] 2 5 6 7 [/SUP], Zahi Fayad[SUP] 2 8 [/SUP], Allan C Just[SUP] 2 9 [/SUP], Alexander W Charney[SUP] 2 6 7 10 11 [/SUP], Shan Zhao[SUP] 1 2 5 [/SUP], Benjamin S Glicksberg[SUP] 1 2 [/SUP], Anuradha Lala[SUP] 12 13 [/SUP], Girish N Nadkarni[SUP] 14 15 16 [/SUP]
Affiliations
Abstract
Background: Data on patients with coronavirus disease 2019 (COVID-19) who return to hospital after discharge are scarce. Characterization of these patients may inform post-hospitalization care.
Objective: To describe clinical characteristics of patients with COVID-19 who returned to the emergency department (ED) or required readmission within 14 days of discharge.
Design: Retrospective cohort study of SARS-COV-2-positive patients with index hospitalization between February 27 and April 12, 2020, with ≥ 14-day follow-up. Significance was defined as P < 0.05 after multiplying P by 125 study-wide comparisons.
Participants: Hospitalized patients with confirmed SARS-CoV-2 discharged alive from five New York City hospitals.
Main measures: Readmission or return to ED following discharge.
Results: Of 2864 discharged patients, 103 (3.6%) returned for emergency care after a median of 4.5 days, with 56 requiring inpatient readmission. The most common reason for return was respiratory distress (50%). Compared with patients who did not return, there were higher proportions of COPD (6.8% vs 2.9%) and hypertension (36% vs 22.1%) among those who returned. Patients who returned also had a shorter median length of stay (LOS) during index hospitalization (4.5 [2.9,9.1] vs 6.7 [3.5, 11.5] days; P[SUB]adjusted[/SUB] = 0.006), and were less likely to have required intensive care on index hospitalization (5.8% vs 19%; P[SUB]adjusted[/SUB] = 0.001). A trend towards association between absence of in-hospital treatment-dose anticoagulation on index admission and return to hospital was also observed (20.9% vs 30.9%, P[SUB]adjusted[/SUB] = 0.06). On readmission, rates of intensive care and death were 5.8% and 3.6%, respectively.
Conclusions: Return to hospital after admission for COVID-19 was infrequent within 14 days of discharge. The most common cause for return was respiratory distress. Patients who returned more likely had COPD and hypertension, shorter LOS on index-hospitalization, and lower rates of in-hospital treatment-dose anticoagulation. Future studies should focus on whether these comorbid conditions, longer LOS, and anticoagulation are associated with reduced readmissions.
. 2020 Aug 19.
doi: 10.1007/s11606-020-06120-6. Online ahead of print.
Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization for COVID-19
Sulaiman S Somani[SUP] 1 2 [/SUP], Felix Richter[SUP] 1 2 [/SUP], Valentin Fuster[SUP] 2 3 [/SUP], Jessica K De Freitas[SUP] 1 2 [/SUP], Nidhi Naik[SUP] 1 2 [/SUP], Keith Sigel[SUP] 2 4 [/SUP], Mount Sinai COVID Informatics Center; Erwin P Bottinger[SUP] 1 2 [/SUP], Matthew A Levin[SUP] 2 5 6 7 [/SUP], Zahi Fayad[SUP] 2 8 [/SUP], Allan C Just[SUP] 2 9 [/SUP], Alexander W Charney[SUP] 2 6 7 10 11 [/SUP], Shan Zhao[SUP] 1 2 5 [/SUP], Benjamin S Glicksberg[SUP] 1 2 [/SUP], Anuradha Lala[SUP] 12 13 [/SUP], Girish N Nadkarni[SUP] 14 15 16 [/SUP]
Affiliations
- PMID: 32815060
- DOI: 10.1007/s11606-020-06120-6
Abstract
Background: Data on patients with coronavirus disease 2019 (COVID-19) who return to hospital after discharge are scarce. Characterization of these patients may inform post-hospitalization care.
Objective: To describe clinical characteristics of patients with COVID-19 who returned to the emergency department (ED) or required readmission within 14 days of discharge.
Design: Retrospective cohort study of SARS-COV-2-positive patients with index hospitalization between February 27 and April 12, 2020, with ≥ 14-day follow-up. Significance was defined as P < 0.05 after multiplying P by 125 study-wide comparisons.
Participants: Hospitalized patients with confirmed SARS-CoV-2 discharged alive from five New York City hospitals.
Main measures: Readmission or return to ED following discharge.
Results: Of 2864 discharged patients, 103 (3.6%) returned for emergency care after a median of 4.5 days, with 56 requiring inpatient readmission. The most common reason for return was respiratory distress (50%). Compared with patients who did not return, there were higher proportions of COPD (6.8% vs 2.9%) and hypertension (36% vs 22.1%) among those who returned. Patients who returned also had a shorter median length of stay (LOS) during index hospitalization (4.5 [2.9,9.1] vs 6.7 [3.5, 11.5] days; P[SUB]adjusted[/SUB] = 0.006), and were less likely to have required intensive care on index hospitalization (5.8% vs 19%; P[SUB]adjusted[/SUB] = 0.001). A trend towards association between absence of in-hospital treatment-dose anticoagulation on index admission and return to hospital was also observed (20.9% vs 30.9%, P[SUB]adjusted[/SUB] = 0.06). On readmission, rates of intensive care and death were 5.8% and 3.6%, respectively.
Conclusions: Return to hospital after admission for COVID-19 was infrequent within 14 days of discharge. The most common cause for return was respiratory distress. Patients who returned more likely had COPD and hypertension, shorter LOS on index-hospitalization, and lower rates of in-hospital treatment-dose anticoagulation. Future studies should focus on whether these comorbid conditions, longer LOS, and anticoagulation are associated with reduced readmissions.