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J Dermatol . Five cases of new-onset pemphigus following vaccinations against coronavirus disease 2019

tetano

Editor, Senior Moderator
J Dermatol


. 2022 Aug 17.
doi: 10.1111/1346-8138.16554. Online ahead of print.
Five cases of new-onset pemphigus following vaccinations against coronavirus disease 2019


Alberto Corrá[SUP] 1 [/SUP], Francesca Barei[SUP] 2 3 [/SUP], Giovanni Genovese[SUP] 2 3 [/SUP], Martina Zussino[SUP] 2 [/SUP], Cristina B Spigariolo[SUP] 2 3 [/SUP], Elena B Mariotti[SUP] 1 [/SUP], Lavinia Quintarelli[SUP] 4 [/SUP], Alice Verdelli[SUP] 4 [/SUP], Marzia Caproni[SUP] 4 [/SUP], Angelo V Marzano[SUP] 2 3 [/SUP]



Affiliations

Abstract

Pemphigus is a group of blistering disorders characterized by the formation of intraepithelial blisters in skin and mucous membranes induced by the binding of circulating autoantibodies to intercellular adhesion molecules. The pathogenesis is complex and not fully understood; however, genetic predisposition and various triggers are widely accepted as key factors in pemphigus development. A few cases of new-onset pemphigus following coronavirus disease 2019 (COVID-19) vaccination have already been published. The present paper reports a total of two cases of pemphigus foliaceous and three cases of pemphigus vulgaris that occurred following vaccinations against COVID-19, with anamnestic, clinical, and diagnostic data collection suggesting assumptions over a possible causal correlation.

Keywords: COVID-19; mRNA BNT162b2; mRNA-1273; pemphigus foliaceus; pemphigus vulgaris.
 
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