tetano
Editor, Senior Moderator
J Crit Care
. 2020 May 29;59:32-34.
doi: 10.1016/j.jcrc.2020.05.017. Online ahead of print.
Clinically Significant Anticardiolipin Antibodies Associated With COVID-19
Sami Hossri[SUP] 1 [/SUP], Mahmoud Shadi[SUP] 2 [/SUP], Zaid Hamarsha[SUP] 3 [/SUP], Rick Schneider[SUP] 3 [/SUP], Dany El-Sayegh[SUP] 1 [/SUP]
Affiliations
Abstract
The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. Both cases reveal significant thrombotic events noted on imaging during their hospital course. Obtaining serial inflammatory markers in conjunction with anti-phospholipid antibody testing revealed clinically significant Antiphospholipid syndrome (APS). This case series reviews the details preceding APS observed in SARS-CoV-2 and aims to report findings that could potentially further our understanding of the disease.
Keywords: Anticardiolipin; Antiphospholipid syndrome; Coagulopathy; Coronarvirus; Covid-19; Critical care; ICU; Infarct; Peripheral arterial disease; SARS-CoV-2; Stroke.
. 2020 May 29;59:32-34.
doi: 10.1016/j.jcrc.2020.05.017. Online ahead of print.
Clinically Significant Anticardiolipin Antibodies Associated With COVID-19
Sami Hossri[SUP] 1 [/SUP], Mahmoud Shadi[SUP] 2 [/SUP], Zaid Hamarsha[SUP] 3 [/SUP], Rick Schneider[SUP] 3 [/SUP], Dany El-Sayegh[SUP] 1 [/SUP]
Affiliations
- PMID: 32512349
- PMCID: PMC7256550
- DOI: 10.1016/j.jcrc.2020.05.017
Abstract
The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. Both cases reveal significant thrombotic events noted on imaging during their hospital course. Obtaining serial inflammatory markers in conjunction with anti-phospholipid antibody testing revealed clinically significant Antiphospholipid syndrome (APS). This case series reviews the details preceding APS observed in SARS-CoV-2 and aims to report findings that could potentially further our understanding of the disease.
Keywords: Anticardiolipin; Antiphospholipid syndrome; Coagulopathy; Coronarvirus; Covid-19; Critical care; ICU; Infarct; Peripheral arterial disease; SARS-CoV-2; Stroke.