Giuseppe
Emeritus
J Clin Microbiol. 2008 Dec 17. [Epub ahead of print]
In vivo and in vitro alterations in influenza A/H3N2 M2 and HA genes: effect of passage in MDCK-SIAT1 cells and conventional MDCK cells.
Li D, Saito R, Suzuki Y, Sato I, Zaraket H, Dapat C, Caperig-Dapat IM, Suzuki H. - Department of Public Health, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan; Yoiko Pediatric Clinic, Niigata, Japan.
No mutations were detected in the hemagglutinin (HA) of influenza A/H3N2 isolates from patients under short-term treatment of amantadine.
However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells.
Our results showed that only a few mutations were observed in MDCK-SIAT1-passaged isolates in the presence of amantadine.
PMID: 19091815 [PubMed - as supplied by publisher]
-
------
In vivo and in vitro alterations in influenza A/H3N2 M2 and HA genes: effect of passage in MDCK-SIAT1 cells and conventional MDCK cells.
Li D, Saito R, Suzuki Y, Sato I, Zaraket H, Dapat C, Caperig-Dapat IM, Suzuki H. - Department of Public Health, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan; Yoiko Pediatric Clinic, Niigata, Japan.
No mutations were detected in the hemagglutinin (HA) of influenza A/H3N2 isolates from patients under short-term treatment of amantadine.
However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells.
Our results showed that only a few mutations were observed in MDCK-SIAT1-passaged isolates in the presence of amantadine.
PMID: 19091815 [PubMed - as supplied by publisher]
-
------