tetano
Editor, Senior Moderator
J Clin Med
. 2022 Sep 28;11(19):5758.
doi: 10.3390/jcm11195758.
Prevalence and Risk Factor Analysis of Post-Intensive Care Syndrome in Patients with COVID-19 Requiring Mechanical Ventilation: A Multicenter Prospective Observational Study
Junji Hatakeyama[SUP] 1 2 [/SUP], Shigeaki Inoue[SUP] 3 [/SUP], Keibun Liu[SUP] 4 [/SUP], Kazuma Yamakawa[SUP] 2 [/SUP], Takeshi Nishida[SUP] 5 [/SUP], Shinichiro Ohshimo[SUP] 6 [/SUP], Satoru Hashimoto[SUP] 7 [/SUP], Naoki Kanda[SUP] 8 [/SUP], Shuhei Maruyama[SUP] 9 [/SUP], Yoshitaka Ogata[SUP] 10 [/SUP], Daisuke Kawakami[SUP] 11 [/SUP], Hiroaki Shimizu[SUP] 12 [/SUP], Katsura Hayakawa[SUP] 13 [/SUP], Aiko Tanaka[SUP] 14 [/SUP], Taku Oshima[SUP] 15 [/SUP], Tatsuya Fuchigami[SUP] 16 [/SUP], Hironori Yawata[SUP] 17 [/SUP], Kyoji Oe[SUP] 18 [/SUP], Akira Kawauchi[SUP] 19 [/SUP], Hidehiro Yamagata[SUP] 20 [/SUP], Masahiro Harada[SUP] 21 [/SUP], Yuichi Sato[SUP] 22 [/SUP], Tomoyuki Nakamura[SUP] 23 [/SUP], Kei Sugiki[SUP] 24 [/SUP], Takahiro Hakozaki[SUP] 25 [/SUP], Satoru Beppu[SUP] 26 [/SUP], Masaki Anraku[SUP] 27 [/SUP], Noboru Kato[SUP] 28 [/SUP], Tomomi Iwashita[SUP] 29 [/SUP], Hiroshi Kamijo[SUP] 30 [/SUP], Yuichiro Kitagawa[SUP] 31 [/SUP], Michio Nagashima[SUP] 32 33 [/SUP], Hirona Nishimaki[SUP] 34 [/SUP], Kentaro Tokuda[SUP] 35 [/SUP], Osamu Nishida[SUP] 23 [/SUP], Kensuke Nakamura[SUP] 36 [/SUP]
Affiliations
Abstract
Introduction: Post-intensive care syndrome (PICS) is an emerging problem in critically ill patients and the prevalence and risk factors are unclear in patients with severe coronavirus disease 2019 (COVID-19). This multicenter prospective observational study aimed to investigate the prevalence and risk factors of PICS in ventilated patients with COVID-19 after ICU discharge.
Methods: Questionnaires were administered twice in surviving patients with COVID-19 who had required mechanical ventilation, concerning Barthel Index, Short-Memory Questionnaire, and Hospital Anxiety and Depression Scale scores. The risk factors for PICS were examined using a multivariate logistic regression analysis.
Results: The first and second PICS surveys were obtained at 5.5 and 13.5 months (mean) after ICU discharge, with 251 and 209 patients completing the questionnaires and with a prevalence of PICS of 58.6% and 60.8%, respectively, along with the highest percentages of cognitive impairment. Delirium (with an odds ratio of (OR) 2.34, 95% CI 1.1-4.9, and p = 0.03) and the duration of mechanical ventilation (with an OR of 1.29, 95% CI 1.05-1.58, and p = 0.02) were independently identified as the risk factors for PICS in the first PICS survey.
Conclusion: Approximately 60% of the ventilated patients with COVID-19 experienced persistent PICS, especially delirium, and required longer mechanical ventilation.
Keywords: COVID-19; critically ill patients; delirium; post-intensive care syndrome.
. 2022 Sep 28;11(19):5758.
doi: 10.3390/jcm11195758.
Prevalence and Risk Factor Analysis of Post-Intensive Care Syndrome in Patients with COVID-19 Requiring Mechanical Ventilation: A Multicenter Prospective Observational Study
Junji Hatakeyama[SUP] 1 2 [/SUP], Shigeaki Inoue[SUP] 3 [/SUP], Keibun Liu[SUP] 4 [/SUP], Kazuma Yamakawa[SUP] 2 [/SUP], Takeshi Nishida[SUP] 5 [/SUP], Shinichiro Ohshimo[SUP] 6 [/SUP], Satoru Hashimoto[SUP] 7 [/SUP], Naoki Kanda[SUP] 8 [/SUP], Shuhei Maruyama[SUP] 9 [/SUP], Yoshitaka Ogata[SUP] 10 [/SUP], Daisuke Kawakami[SUP] 11 [/SUP], Hiroaki Shimizu[SUP] 12 [/SUP], Katsura Hayakawa[SUP] 13 [/SUP], Aiko Tanaka[SUP] 14 [/SUP], Taku Oshima[SUP] 15 [/SUP], Tatsuya Fuchigami[SUP] 16 [/SUP], Hironori Yawata[SUP] 17 [/SUP], Kyoji Oe[SUP] 18 [/SUP], Akira Kawauchi[SUP] 19 [/SUP], Hidehiro Yamagata[SUP] 20 [/SUP], Masahiro Harada[SUP] 21 [/SUP], Yuichi Sato[SUP] 22 [/SUP], Tomoyuki Nakamura[SUP] 23 [/SUP], Kei Sugiki[SUP] 24 [/SUP], Takahiro Hakozaki[SUP] 25 [/SUP], Satoru Beppu[SUP] 26 [/SUP], Masaki Anraku[SUP] 27 [/SUP], Noboru Kato[SUP] 28 [/SUP], Tomomi Iwashita[SUP] 29 [/SUP], Hiroshi Kamijo[SUP] 30 [/SUP], Yuichiro Kitagawa[SUP] 31 [/SUP], Michio Nagashima[SUP] 32 33 [/SUP], Hirona Nishimaki[SUP] 34 [/SUP], Kentaro Tokuda[SUP] 35 [/SUP], Osamu Nishida[SUP] 23 [/SUP], Kensuke Nakamura[SUP] 36 [/SUP]
Affiliations
- PMID: 36233627
- DOI: 10.3390/jcm11195758
Abstract
Introduction: Post-intensive care syndrome (PICS) is an emerging problem in critically ill patients and the prevalence and risk factors are unclear in patients with severe coronavirus disease 2019 (COVID-19). This multicenter prospective observational study aimed to investigate the prevalence and risk factors of PICS in ventilated patients with COVID-19 after ICU discharge.
Methods: Questionnaires were administered twice in surviving patients with COVID-19 who had required mechanical ventilation, concerning Barthel Index, Short-Memory Questionnaire, and Hospital Anxiety and Depression Scale scores. The risk factors for PICS were examined using a multivariate logistic regression analysis.
Results: The first and second PICS surveys were obtained at 5.5 and 13.5 months (mean) after ICU discharge, with 251 and 209 patients completing the questionnaires and with a prevalence of PICS of 58.6% and 60.8%, respectively, along with the highest percentages of cognitive impairment. Delirium (with an odds ratio of (OR) 2.34, 95% CI 1.1-4.9, and p = 0.03) and the duration of mechanical ventilation (with an OR of 1.29, 95% CI 1.05-1.58, and p = 0.02) were independently identified as the risk factors for PICS in the first PICS survey.
Conclusion: Approximately 60% of the ventilated patients with COVID-19 experienced persistent PICS, especially delirium, and required longer mechanical ventilation.
Keywords: COVID-19; critically ill patients; delirium; post-intensive care syndrome.