tetano
Editor, Senior Moderator
J Clin Med
. 2020 Jul 14;9(7):E2227.
doi: 10.3390/jcm9072227.
Epidemiology and Clinical Presentation of Children Hospitalized with SARS-CoV-2 Infection in Suburbs of Paris
Louise Gaborieau[SUP] 1 2 [/SUP], Celine Delestrain[SUP] 1 3 4 5 [/SUP], Philippe Bensaid[SUP] 6 [/SUP], Audrey Vizeneux[SUP] 6 [/SUP], Philippe Blanc[SUP] 7 [/SUP], Aur?lie Garraffo[SUP] 8 [/SUP], Emilie Georget[SUP] 8 [/SUP], Arnaud Chalvon[SUP] 9 [/SUP], Nathalie Garrec[SUP] 9 [/SUP], Yacine Laoudi[SUP] 10 [/SUP], Emmanuelle Varon[SUP] 11 12 [/SUP], S?bastien Rouget[SUP] 13 [/SUP], Alexandre Pupin[SUP] 13 [/SUP], Khaled Abdel Aal[SUP] 14 [/SUP], David Toulorge[SUP] 14 [/SUP], Sarah Ducrocq[SUP] 15 [/SUP], Catherine Barrey[SUP] 16 [/SUP], Letitia Pantalone[SUP] 17 [/SUP], Blandine Robert[SUP] 17 [/SUP], Lydie Joly-Sanchez[SUP] 18 [/SUP], Caroline Thach[SUP] 18 [/SUP], Caroline Masserot-Lureau[SUP] 19 [/SUP], Jamil? Chahine[SUP] 20 [/SUP], Veronica Risso Garcia-Roudaut[SUP] 21 [/SUP], Jonathan Rozental[SUP] 22 [/SUP], Sylvie Nathanson[SUP] 23 [/SUP], Mohamed Khaled[SUP] 24 [/SUP], Alexis Mandelcwajg[SUP] 25 [/SUP], Nadia Demayer[SUP] 26 [/SUP], St?phanie Muller[SUP] 27 [/SUP], Mustapha Mazerghane[SUP] 28 [/SUP], Ralph Epaud[SUP] 1 3 4 5 [/SUP], B?atrice Pellegrino[SUP] 29 [/SUP], Fouad Madhi[SUP] 1 5 30 [/SUP]
Affiliations
Abstract
Understanding the clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and prognosis in children is a major issue. Children often present mild symptoms, and some severe forms require paediatric intensive care, with in some cases a fatal prognosis. Our aim was to identify the epidemiological characteristics, clinical presentation, and prognosis of children with coronavirus disease 2019 (Covid-19) hospitalized in Paris suburb hospitals. In this prospective, observational, multicentre study, we included children hospitalized in paediatric departments of Paris suburb hospitals from 23 March 2020 to 10 May 2020, during the national lockdown in France with confirmed SARS-CoV-2 infection (positive RNA test on a nasopharyngeal swab) or highly suspected infection (clinical, biological, and/or radiological data features suggestive for SARS-CoV-2 infection). A total of 192 children were included for confirmed (n = 157) or highly suspected (n = 35) SARS-CoV-2 infection. The median age was one year old (interquartile range 0.125-11) with a sex ratio 1.3:1. Fever was recorded in 147 (76.6%) children and considered poorly tolerated in 29 (15.1%). The symptoms ranged from rhinorrhoea (34.4%) and gastrointestinal (35.5%) to respiratory distress (25%). Only 10 (5.2%) children had anosmia and five (2.6%) had chest pain. An underlying condition was identified in almost 30% of the children in our study. Overall, 24 (12.5%) children were admitted to paediatric intensive care units, 12 required mechanical ventilation, and three died. For children in Paris suburbs, most cases of Covid-19 showed mild or moderate clinical expression. However, one-eighth of children were admitted to paediatric intensive care units and three died.
Keywords: SARS-Co2 infection; clinical presentation; hospitalized children.
. 2020 Jul 14;9(7):E2227.
doi: 10.3390/jcm9072227.
Epidemiology and Clinical Presentation of Children Hospitalized with SARS-CoV-2 Infection in Suburbs of Paris
Louise Gaborieau[SUP] 1 2 [/SUP], Celine Delestrain[SUP] 1 3 4 5 [/SUP], Philippe Bensaid[SUP] 6 [/SUP], Audrey Vizeneux[SUP] 6 [/SUP], Philippe Blanc[SUP] 7 [/SUP], Aur?lie Garraffo[SUP] 8 [/SUP], Emilie Georget[SUP] 8 [/SUP], Arnaud Chalvon[SUP] 9 [/SUP], Nathalie Garrec[SUP] 9 [/SUP], Yacine Laoudi[SUP] 10 [/SUP], Emmanuelle Varon[SUP] 11 12 [/SUP], S?bastien Rouget[SUP] 13 [/SUP], Alexandre Pupin[SUP] 13 [/SUP], Khaled Abdel Aal[SUP] 14 [/SUP], David Toulorge[SUP] 14 [/SUP], Sarah Ducrocq[SUP] 15 [/SUP], Catherine Barrey[SUP] 16 [/SUP], Letitia Pantalone[SUP] 17 [/SUP], Blandine Robert[SUP] 17 [/SUP], Lydie Joly-Sanchez[SUP] 18 [/SUP], Caroline Thach[SUP] 18 [/SUP], Caroline Masserot-Lureau[SUP] 19 [/SUP], Jamil? Chahine[SUP] 20 [/SUP], Veronica Risso Garcia-Roudaut[SUP] 21 [/SUP], Jonathan Rozental[SUP] 22 [/SUP], Sylvie Nathanson[SUP] 23 [/SUP], Mohamed Khaled[SUP] 24 [/SUP], Alexis Mandelcwajg[SUP] 25 [/SUP], Nadia Demayer[SUP] 26 [/SUP], St?phanie Muller[SUP] 27 [/SUP], Mustapha Mazerghane[SUP] 28 [/SUP], Ralph Epaud[SUP] 1 3 4 5 [/SUP], B?atrice Pellegrino[SUP] 29 [/SUP], Fouad Madhi[SUP] 1 5 30 [/SUP]
Affiliations
- PMID: 32674306
- DOI: 10.3390/jcm9072227
Abstract
Understanding the clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and prognosis in children is a major issue. Children often present mild symptoms, and some severe forms require paediatric intensive care, with in some cases a fatal prognosis. Our aim was to identify the epidemiological characteristics, clinical presentation, and prognosis of children with coronavirus disease 2019 (Covid-19) hospitalized in Paris suburb hospitals. In this prospective, observational, multicentre study, we included children hospitalized in paediatric departments of Paris suburb hospitals from 23 March 2020 to 10 May 2020, during the national lockdown in France with confirmed SARS-CoV-2 infection (positive RNA test on a nasopharyngeal swab) or highly suspected infection (clinical, biological, and/or radiological data features suggestive for SARS-CoV-2 infection). A total of 192 children were included for confirmed (n = 157) or highly suspected (n = 35) SARS-CoV-2 infection. The median age was one year old (interquartile range 0.125-11) with a sex ratio 1.3:1. Fever was recorded in 147 (76.6%) children and considered poorly tolerated in 29 (15.1%). The symptoms ranged from rhinorrhoea (34.4%) and gastrointestinal (35.5%) to respiratory distress (25%). Only 10 (5.2%) children had anosmia and five (2.6%) had chest pain. An underlying condition was identified in almost 30% of the children in our study. Overall, 24 (12.5%) children were admitted to paediatric intensive care units, 12 required mechanical ventilation, and three died. For children in Paris suburbs, most cases of Covid-19 showed mild or moderate clinical expression. However, one-eighth of children were admitted to paediatric intensive care units and three died.
Keywords: SARS-Co2 infection; clinical presentation; hospitalized children.