tetano
Editor, Senior Moderator
J Clin Med
. 2022 Apr 9;11(8):2102.
doi: 10.3390/jcm11082102.
Comparisons of Clinical Features and Outcomes of COVID-19 between Patients with Pediatric Onset Inflammatory Rheumatic Diseases and Healthy Children
Fatih Haslak[SUP] 1 [/SUP], Sevki Erdem Varol[SUP] 1 [/SUP], Aybuke Gunalp[SUP] 1 [/SUP], Ozge Kaynar[SUP] 1 [/SUP], Mehmet Yildiz[SUP] 1 [/SUP], Amra Adrovic[SUP] 1 [/SUP], Sezgin Sahin[SUP] 1 [/SUP], Gulsen Kes[SUP] 2 [/SUP], Ayse Ayzit-Kilinc[SUP] 3 [/SUP], Beste Akdeniz[SUP] 2 [/SUP], Pinar Onal[SUP] 2 [/SUP], Gozde Apaydin[SUP] 2 [/SUP], Deniz Aygun[SUP] 2 [/SUP], Huseyin Arslan[SUP] 3 [/SUP], Azer Kilic-Baskan[SUP] 3 [/SUP], Evrim Hepkaya[SUP] 3 [/SUP], Ozge Meral[SUP] 3 [/SUP], Kenan Barut[SUP] 1 [/SUP], Haluk Cezmi Cokugras[SUP] 2 [/SUP], Ozgur Kasapcopur[SUP] 1 [/SUP]
Affiliations
Abstract
(1) Background: We aimed to describe the clinical features and outcomes of coronavirus disease-2019 (COVID-19) in children and late adolescents with inflammatory rheumatic diseases (IRD) and to measure their severity risks by comparing them with healthy children. (2) Methods: Among children and late adolescents found to be severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) positive via polymerase chain reaction (PCR) test, IRD patients with an at least six-months follow-up duration, and healthy children were included in the study. Data were obtained retrospectively. (3) Results: A total of 658 (339 (51.5%) females) (healthy children: 506, IRD patients: 152) subjects were included in the study. While 570 of 658 (86.6%) experienced COVID-19-related symptoms, only 21 (3.19%) required hospitalization with a median duration of 5 (1-30) days. Fever, dry cough, and fatigue were the most common symptoms. None of evaluated subjects died, and all recovered without any significant sequelae. The presence of any IRD was found to increase the risk of both hospitalization (OR: 5.205; 95% CI: 2.003-13.524) and symptomatic infection (OR: 2.579; 95% CI: 1.068-6.228). Furthermore, increasing age was significantly associated with symptomatic infection (OR: 1.051; 95% CI: 1.009-1.095). (4) Conclusions: Our study emphasizes that pediatric rheumatologists should monitor their patients closely for relatively poor COVID-19 outcomes.
Keywords: COVID-19; SARS-CoV-2; familial Mediterranean fever; pediatrics; rheumatology.
. 2022 Apr 9;11(8):2102.
doi: 10.3390/jcm11082102.
Comparisons of Clinical Features and Outcomes of COVID-19 between Patients with Pediatric Onset Inflammatory Rheumatic Diseases and Healthy Children
Fatih Haslak[SUP] 1 [/SUP], Sevki Erdem Varol[SUP] 1 [/SUP], Aybuke Gunalp[SUP] 1 [/SUP], Ozge Kaynar[SUP] 1 [/SUP], Mehmet Yildiz[SUP] 1 [/SUP], Amra Adrovic[SUP] 1 [/SUP], Sezgin Sahin[SUP] 1 [/SUP], Gulsen Kes[SUP] 2 [/SUP], Ayse Ayzit-Kilinc[SUP] 3 [/SUP], Beste Akdeniz[SUP] 2 [/SUP], Pinar Onal[SUP] 2 [/SUP], Gozde Apaydin[SUP] 2 [/SUP], Deniz Aygun[SUP] 2 [/SUP], Huseyin Arslan[SUP] 3 [/SUP], Azer Kilic-Baskan[SUP] 3 [/SUP], Evrim Hepkaya[SUP] 3 [/SUP], Ozge Meral[SUP] 3 [/SUP], Kenan Barut[SUP] 1 [/SUP], Haluk Cezmi Cokugras[SUP] 2 [/SUP], Ozgur Kasapcopur[SUP] 1 [/SUP]
Affiliations
- PMID: 35456195
- PMCID: PMC9030434
- DOI: 10.3390/jcm11082102
Abstract
(1) Background: We aimed to describe the clinical features and outcomes of coronavirus disease-2019 (COVID-19) in children and late adolescents with inflammatory rheumatic diseases (IRD) and to measure their severity risks by comparing them with healthy children. (2) Methods: Among children and late adolescents found to be severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) positive via polymerase chain reaction (PCR) test, IRD patients with an at least six-months follow-up duration, and healthy children were included in the study. Data were obtained retrospectively. (3) Results: A total of 658 (339 (51.5%) females) (healthy children: 506, IRD patients: 152) subjects were included in the study. While 570 of 658 (86.6%) experienced COVID-19-related symptoms, only 21 (3.19%) required hospitalization with a median duration of 5 (1-30) days. Fever, dry cough, and fatigue were the most common symptoms. None of evaluated subjects died, and all recovered without any significant sequelae. The presence of any IRD was found to increase the risk of both hospitalization (OR: 5.205; 95% CI: 2.003-13.524) and symptomatic infection (OR: 2.579; 95% CI: 1.068-6.228). Furthermore, increasing age was significantly associated with symptomatic infection (OR: 1.051; 95% CI: 1.009-1.095). (4) Conclusions: Our study emphasizes that pediatric rheumatologists should monitor their patients closely for relatively poor COVID-19 outcomes.
Keywords: COVID-19; SARS-CoV-2; familial Mediterranean fever; pediatrics; rheumatology.