tetano
Editor, Senior Moderator
J Clin Med
. 2026 May 28;15(11):4192.
doi: 10.3390/jcm15114192.
Clinical and Immunovirological Characteristics Associated with Cardiovascular Dysautonomia in Long COVID
Yves Renaudineau[SUP] 1 2 [/SUP], Selena Teillaud[SUP] 1 [/SUP], Sébastien De Almeida Chaves[SUP] 3 [/SUP], Muriel Alvarez[SUP] 4 [/SUP], Romain Barthes[SUP] 5 [/SUP], Chloé Bost[SUP] 1 2 [/SUP], Françoise Fortenfant[SUP] 1 [/SUP], Bénédicte Puissant-Lubrano[SUP] 1 2 [/SUP], Florence Abravanel[SUP] 6 [/SUP], Camille Vellas[SUP] 6 [/SUP], Anne Pavy-Le Traon[SUP] 7 [/SUP], Laurent Sailler[SUP] 3 [/SUP]
Affiliations
Background/Objectives: This report is an assessment of the characteristics associated with cardiovascular dysautonomia (CVD) in the context of long Coronavirus disease (COVID), which is currently inadequately characterized. Material and Methods: A retrospective cross-sectional study was performed involving 106 patients with long COVID, including 34 individuals diagnosed with CVD, among whom eight met the criteria for Postural Tachycardia Syndrome (PoTS). The variables assessed encompassed individual characteristics (e.g., age, sex, comorbidities), immunization parameters (e.g., vaccination/viral status, timing, frequency), cellular and humoral anti-Spike and anti-Nucleocapsid (Nuc) immune responses, inflammatory and allergic biomarkers, as well as an extensive panel of common autoantibodies comprising anti-nuclear antibodies, anti-central nervous system antibodies (cerebellum, brain), and anti-peripheral nervous system antibodies (gangliosides). Results: An age < 45 years, body mass index, hyperventilation syndrome as well as a higher cumulative number of antigenic contacts (vaccinations plus infections ≥ 3) and an elevated basophil count (≥0.06 G/L) were independently associated with CVD. There was no association between CVD and inflammatory markers or common autoantibodies. Patients with PoTS criteria had a strong anti-Spike cellular immune response and increased IgG anti-Nuc humoral immunity when compared with CVD and non-CVD long COVID counterparts. Conclusions: Compared to other long COVID patients, patients with long COVID-associated CVD have distinctive clinical and immunovirological features. Our results suggest the potential role of the immune response against Spike and of allergic pathways rather than humoral autoimmunity against common autoantibodies in long COVID CVD.
Keywords: Postural Tachycardia Syndrome; age; allergy; anti-viral; autoimmunity; cardiovascular dysautonomia; inflammation; long COVID; obesity.
. 2026 May 28;15(11):4192.
doi: 10.3390/jcm15114192.
Clinical and Immunovirological Characteristics Associated with Cardiovascular Dysautonomia in Long COVID
Yves Renaudineau[SUP] 1 2 [/SUP], Selena Teillaud[SUP] 1 [/SUP], Sébastien De Almeida Chaves[SUP] 3 [/SUP], Muriel Alvarez[SUP] 4 [/SUP], Romain Barthes[SUP] 5 [/SUP], Chloé Bost[SUP] 1 2 [/SUP], Françoise Fortenfant[SUP] 1 [/SUP], Bénédicte Puissant-Lubrano[SUP] 1 2 [/SUP], Florence Abravanel[SUP] 6 [/SUP], Camille Vellas[SUP] 6 [/SUP], Anne Pavy-Le Traon[SUP] 7 [/SUP], Laurent Sailler[SUP] 3 [/SUP]
Affiliations
- PMID: 42279051
- PMCID: PMC13257762
- DOI: 10.3390/jcm15114192
Background/Objectives: This report is an assessment of the characteristics associated with cardiovascular dysautonomia (CVD) in the context of long Coronavirus disease (COVID), which is currently inadequately characterized. Material and Methods: A retrospective cross-sectional study was performed involving 106 patients with long COVID, including 34 individuals diagnosed with CVD, among whom eight met the criteria for Postural Tachycardia Syndrome (PoTS). The variables assessed encompassed individual characteristics (e.g., age, sex, comorbidities), immunization parameters (e.g., vaccination/viral status, timing, frequency), cellular and humoral anti-Spike and anti-Nucleocapsid (Nuc) immune responses, inflammatory and allergic biomarkers, as well as an extensive panel of common autoantibodies comprising anti-nuclear antibodies, anti-central nervous system antibodies (cerebellum, brain), and anti-peripheral nervous system antibodies (gangliosides). Results: An age < 45 years, body mass index, hyperventilation syndrome as well as a higher cumulative number of antigenic contacts (vaccinations plus infections ≥ 3) and an elevated basophil count (≥0.06 G/L) were independently associated with CVD. There was no association between CVD and inflammatory markers or common autoantibodies. Patients with PoTS criteria had a strong anti-Spike cellular immune response and increased IgG anti-Nuc humoral immunity when compared with CVD and non-CVD long COVID counterparts. Conclusions: Compared to other long COVID patients, patients with long COVID-associated CVD have distinctive clinical and immunovirological features. Our results suggest the potential role of the immune response against Spike and of allergic pathways rather than humoral autoimmunity against common autoantibodies in long COVID CVD.
Keywords: Postural Tachycardia Syndrome; age; allergy; anti-viral; autoimmunity; cardiovascular dysautonomia; inflammation; long COVID; obesity.