tetano
Editor, Senior Moderator
J Clin Lab Anal
. 2021 Dec 7;e24162.
doi: 10.1002/jcla.24162. Online ahead of print.
Association between serum inflammatory parameters and the disease severity in COVID-19 patients
Rajab Mardani[SUP] 1 [/SUP], Mehrnoush Namavar[SUP] 2 [/SUP], Elham Ghorbi[SUP] 2 [/SUP], Zabihollah Shoja[SUP] 3 [/SUP], Fatemeh Zali[SUP] 4 [/SUP], Hooman Kaghazian[SUP] 2 5 [/SUP], Mohammad Reza Aghasadeghi[SUP] 2 6 [/SUP], Seyed Amir Sadeghi[SUP] 2 6 [/SUP], Shahram Sabeti[SUP] 7 [/SUP], Ilad Alavi Darazam[SUP] 8 [/SUP], Nayebali Ahmadi[SUP] 9 [/SUP], Seyed Dawood Mousavi-Nasab[SUP] 2 5 [/SUP]
Affiliations
Abstract
Objective: Most patients infected with the novel coronavirus (SARS-CoV-2), as the causative agent of COVID-19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID-19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity.
Methods: In this prospective cross-sectional study, 50 patients with COVID-19 and 20 patients without COVID-19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non-severe and severe. Differences in the serum levels of C-reactive protein (CRP), IL-6, and TNF-α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed.
Results: Out of the 50 patients with COVID-19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID-19 patients in terms of gender and age. Blood tests of COVID-19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL-6, TNF-α, and CRP between the severe and non-severe groups, which were higher in the severe group. Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL-6 (r = 0.74), LYM with NEU (r = -0.97), and ESR with TNF-α (r = 0.7).
Conclusion: The findings of this study, as the first study in Iran, suggest that the levels of IL-6, TNF-α, ESR, and CRP could be used to predict the severity of COVID-19 disease.
Keywords: COVID-19; CRP; IL-6; SARS-CoV-2; TNF-α; cytokines.
. 2021 Dec 7;e24162.
doi: 10.1002/jcla.24162. Online ahead of print.
Association between serum inflammatory parameters and the disease severity in COVID-19 patients
Rajab Mardani[SUP] 1 [/SUP], Mehrnoush Namavar[SUP] 2 [/SUP], Elham Ghorbi[SUP] 2 [/SUP], Zabihollah Shoja[SUP] 3 [/SUP], Fatemeh Zali[SUP] 4 [/SUP], Hooman Kaghazian[SUP] 2 5 [/SUP], Mohammad Reza Aghasadeghi[SUP] 2 6 [/SUP], Seyed Amir Sadeghi[SUP] 2 6 [/SUP], Shahram Sabeti[SUP] 7 [/SUP], Ilad Alavi Darazam[SUP] 8 [/SUP], Nayebali Ahmadi[SUP] 9 [/SUP], Seyed Dawood Mousavi-Nasab[SUP] 2 5 [/SUP]
Affiliations
- PMID: 34874079
- DOI: 10.1002/jcla.24162
Abstract
Objective: Most patients infected with the novel coronavirus (SARS-CoV-2), as the causative agent of COVID-19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID-19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity.
Methods: In this prospective cross-sectional study, 50 patients with COVID-19 and 20 patients without COVID-19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non-severe and severe. Differences in the serum levels of C-reactive protein (CRP), IL-6, and TNF-α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed.
Results: Out of the 50 patients with COVID-19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID-19 patients in terms of gender and age. Blood tests of COVID-19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL-6, TNF-α, and CRP between the severe and non-severe groups, which were higher in the severe group. Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL-6 (r = 0.74), LYM with NEU (r = -0.97), and ESR with TNF-α (r = 0.7).
Conclusion: The findings of this study, as the first study in Iran, suggest that the levels of IL-6, TNF-α, ESR, and CRP could be used to predict the severity of COVID-19 disease.
Keywords: COVID-19; CRP; IL-6; SARS-CoV-2; TNF-α; cytokines.