tetano
Editor, Senior Moderator
J Clin Invest
. 2026 Mar 16;136(6):e203781.
doi: 10.1172/JCI203781.
Hitting the hidden: arming the immune system for the next zoonotic coronavirus spillover
Charlie Fricke, Stanley Perlman
Coronaviruses, both known and yet to emerge, pose persistent zoonotic and pandemic threats. While current parenteral COVID-19 mRNA vaccines effectively mitigate severe disease caused by SARS-CoV-2, they primarily elicit systemic immunity restricted to specific variants within clade 1b of the sarbecovirus subgenus and provide limited mucosal protection. Addressing these shortcomings, Cheang et al. developed a DC-targeting intranasal booster vaccine that induces robust and durable mucosal and systemic immunity across sarbecovirus clades 1a and 1b. This study highlights a promising strategy for pan-sarbecovirus vaccines by leveraging mucosal immune induction to prevent viral transmission and enhance pandemic preparedness.
. 2026 Mar 16;136(6):e203781.
doi: 10.1172/JCI203781.
Hitting the hidden: arming the immune system for the next zoonotic coronavirus spillover
Charlie Fricke, Stanley Perlman
- PMID: 41837282
- PMCID: PMC12987610
- DOI: 10.1172/JCI203781
Coronaviruses, both known and yet to emerge, pose persistent zoonotic and pandemic threats. While current parenteral COVID-19 mRNA vaccines effectively mitigate severe disease caused by SARS-CoV-2, they primarily elicit systemic immunity restricted to specific variants within clade 1b of the sarbecovirus subgenus and provide limited mucosal protection. Addressing these shortcomings, Cheang et al. developed a DC-targeting intranasal booster vaccine that induces robust and durable mucosal and systemic immunity across sarbecovirus clades 1a and 1b. This study highlights a promising strategy for pan-sarbecovirus vaccines by leveraging mucosal immune induction to prevent viral transmission and enhance pandemic preparedness.