tetano
Editor, Senior Moderator
J Clin Immunol
. 2024 Nov 30;45(1):51.
doi: 10.1007/s10875-024-01845-z. Nationwide Survey of Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019 in Japan
Daisuke Matsubara[SUP] #[/SUP][SUP] 1 [/SUP], Yuri Matsubara[SUP] #[/SUP][SUP] 2 [/SUP], Mamoru Ayusawa[SUP] 3 [/SUP], Hiromichi Hamada[SUP] 4 [/SUP], Mitsuru Seki[SUP] 5 [/SUP], Hiroyuki Yamagishi[SUP] 6 [/SUP], Yoshihide Mitani[SUP] 7 [/SUP], Yoshihiro Onouchi[SUP] 8 [/SUP], Hiroyuki Moriuchi[SUP] 9 [/SUP], Isao Miyairi[SUP] 10 [/SUP], Keiko Tanaka-Taya[SUP] 11 [/SUP], Tomohiro Katsuta[SUP] 12 [/SUP], Hiroshi Kurosawa[SUP] 13 [/SUP], Kazunori Aoki[SUP] 13 [/SUP], Naoki Shimizu[SUP] 12 [/SUP], Yosikazu Nakamura[SUP] 14 [/SUP]
Affiliations
Background: Multisystem inflammatory syndrome in children (MIS-C) presents some clinical overlap with Kawasaki disease (KD). Although KD is common in Japan, the clinical characteristics of MIS-C in Japan remain unknown. Therefore, we aimed to determine the epidemiological and clinical features of MIS-C in Japan.
Methods: Using a case reporting form, a nationwide registry was created between November 2020 and March 2023, involving 2,080 facilities throughout Japan. We prospectively and retrospectively enrolled patients with MIS-C. The primary outcomes were the number and incidence rates of children with MIS-C. The secondary outcomes included clinical features, such as KD phenotype, organ involvement, shock, intensive care unit admission, and coronary artery lesions.
Results: Among 398 patients registered, central review identified 129 MIS-C cases (mean age: 8·8 ± 3·7 years). The overall incidence rate was estimated to be 1·5 per 100,000 COVID-19 cases, exhibiting a decline as the COVID-19 pandemic progressed, from 12·3 cases (Pre-Delta) to 1·3 cases (Omicron); 80% of MIS-C cases occurred during the Omicron variant predominant period, and 72% of children with MIS-C met the KD criteria. Cardiovascular (88%) and gastrointestinal (90%) involvement were frequent. In Japan, MIS-C cases showed comparatively less severe clinical features, with shock in 29% and admission to the intensive care unit in 12% of cases. Coronary artery lesions were identified in 15 cases (11·6%), irrespective of the presence of shock. No fatalities were reported.
Conclusion: The incidence of MIS-C was low in Japan. The clinical features distinctively exhibited a more KD-like phenotype, with less severe clinical features.
Keywords: COVID-19; Kawasaki disease; incidence; multisystem inflammatory syndrome in children.
. 2024 Nov 30;45(1):51.
doi: 10.1007/s10875-024-01845-z. Nationwide Survey of Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019 in Japan
Daisuke Matsubara[SUP] #[/SUP][SUP] 1 [/SUP], Yuri Matsubara[SUP] #[/SUP][SUP] 2 [/SUP], Mamoru Ayusawa[SUP] 3 [/SUP], Hiromichi Hamada[SUP] 4 [/SUP], Mitsuru Seki[SUP] 5 [/SUP], Hiroyuki Yamagishi[SUP] 6 [/SUP], Yoshihide Mitani[SUP] 7 [/SUP], Yoshihiro Onouchi[SUP] 8 [/SUP], Hiroyuki Moriuchi[SUP] 9 [/SUP], Isao Miyairi[SUP] 10 [/SUP], Keiko Tanaka-Taya[SUP] 11 [/SUP], Tomohiro Katsuta[SUP] 12 [/SUP], Hiroshi Kurosawa[SUP] 13 [/SUP], Kazunori Aoki[SUP] 13 [/SUP], Naoki Shimizu[SUP] 12 [/SUP], Yosikazu Nakamura[SUP] 14 [/SUP]
Affiliations
- PMID: 39613902
- DOI: 10.1007/s10875-024-01845-z
Background: Multisystem inflammatory syndrome in children (MIS-C) presents some clinical overlap with Kawasaki disease (KD). Although KD is common in Japan, the clinical characteristics of MIS-C in Japan remain unknown. Therefore, we aimed to determine the epidemiological and clinical features of MIS-C in Japan.
Methods: Using a case reporting form, a nationwide registry was created between November 2020 and March 2023, involving 2,080 facilities throughout Japan. We prospectively and retrospectively enrolled patients with MIS-C. The primary outcomes were the number and incidence rates of children with MIS-C. The secondary outcomes included clinical features, such as KD phenotype, organ involvement, shock, intensive care unit admission, and coronary artery lesions.
Results: Among 398 patients registered, central review identified 129 MIS-C cases (mean age: 8·8 ± 3·7 years). The overall incidence rate was estimated to be 1·5 per 100,000 COVID-19 cases, exhibiting a decline as the COVID-19 pandemic progressed, from 12·3 cases (Pre-Delta) to 1·3 cases (Omicron); 80% of MIS-C cases occurred during the Omicron variant predominant period, and 72% of children with MIS-C met the KD criteria. Cardiovascular (88%) and gastrointestinal (90%) involvement were frequent. In Japan, MIS-C cases showed comparatively less severe clinical features, with shock in 29% and admission to the intensive care unit in 12% of cases. Coronary artery lesions were identified in 15 cases (11·6%), irrespective of the presence of shock. No fatalities were reported.
Conclusion: The incidence of MIS-C was low in Japan. The clinical features distinctively exhibited a more KD-like phenotype, with less severe clinical features.
Keywords: COVID-19; Kawasaki disease; incidence; multisystem inflammatory syndrome in children.