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Editor, Senior Moderator
J Cell Mol Med. 2020 Apr 12. doi: 10.1111/jcmm.15312. [Epub ahead of print]
G6PD and chloroquine: selecting the treatment against SARS-CoV-2?
Kassi EN[SUP]1[/SUP], Papavassiliou KA[SUP]1[/SUP], Papavassiliou AG[SUP]1[/SUP].
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Abstract
In light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) pandemic and the possible widespread use of chloroquine (a member of the drug class 4-aminoquinoline primarily used to prevent and treat malaria and amebiasis) and its derivatives (e.g. hydroxychloroquine, a metabolite of chloroquine),[SUP]1[/SUP] a safety issue is addressed, concerning the selection of patients suitable to receive it. HCov-229E is one of the four flu-causing coronaviruses which share great sequence similitude, while many symptoms of patients infected with COVID-19 resemble those of patients infected with these known flu-causing coronaviruses.[SUP]2[/SUP] A previous study reported that human lung epithelial A549 cells treated with glucose 6-phosphate dehydrogenase (G6PD) interfering RNA (RNAi) to lower G6PD activity displayed augmented (12-fold) viral production in comparison to normal counterparts when infected with coronavirus HCov-229E. Moreover, viral replication in these G6PD-deficient cells was found to be 3-fold higher than normal cells, following a 10-h incubation, as estimated by quantitative polymerase chain reaction (qPCR).[SUP]3[/SUP] G6PD deficiency remains the most common human enzymatic disorder of red blood cells worldwide.
This article is protected by copyright. All rights reserved.
PMID:32281268DOI:10.1111/jcmm.15312
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G6PD and chloroquine: selecting the treatment against SARS-CoV-2?
Kassi EN[SUP]1[/SUP], Papavassiliou KA[SUP]1[/SUP], Papavassiliou AG[SUP]1[/SUP].
Author information
Abstract
In light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) pandemic and the possible widespread use of chloroquine (a member of the drug class 4-aminoquinoline primarily used to prevent and treat malaria and amebiasis) and its derivatives (e.g. hydroxychloroquine, a metabolite of chloroquine),[SUP]1[/SUP] a safety issue is addressed, concerning the selection of patients suitable to receive it. HCov-229E is one of the four flu-causing coronaviruses which share great sequence similitude, while many symptoms of patients infected with COVID-19 resemble those of patients infected with these known flu-causing coronaviruses.[SUP]2[/SUP] A previous study reported that human lung epithelial A549 cells treated with glucose 6-phosphate dehydrogenase (G6PD) interfering RNA (RNAi) to lower G6PD activity displayed augmented (12-fold) viral production in comparison to normal counterparts when infected with coronavirus HCov-229E. Moreover, viral replication in these G6PD-deficient cells was found to be 3-fold higher than normal cells, following a 10-h incubation, as estimated by quantitative polymerase chain reaction (qPCR).[SUP]3[/SUP] G6PD deficiency remains the most common human enzymatic disorder of red blood cells worldwide.
This article is protected by copyright. All rights reserved.
PMID:32281268DOI:10.1111/jcmm.15312
Free full text