tetano
Editor, Senior Moderator
J Card Surg
. 2021 Jul 22.
doi: 10.1111/jocs.15833. Online ahead of print.
Extracorporeal membrane oxygenation (ECMO) for critically ill patients with coronavirus disease 2019 (COVID-19): A retrospective cohort study
Shuanglei Li[SUP] 1 [/SUP], Jing Xiong[SUP] 2 [/SUP], Zhongtao Du[SUP] 3 [/SUP], Wei Lai[SUP] 4 [/SUP], Xinhua Ma[SUP] 5 [/SUP], Zhichun Feng[SUP] 1 [/SUP], Yuan Shi[SUP] 2 [/SUP], Xiaoyang Hong[SUP] 1 [/SUP], Yundai Chen[SUP] 1 [/SUP]
Affiliations
Abstract
Purpose: The role of extracorporeal membrane oxygenatio (ECMO) for rescue therapy of respiratory failure in critically ill coronavirus disease 2019 (COVID-19) patients remains controversial. We aimed to evaluate the clinical outcomes of ECMO in the treatment of COVID-19 compared with conventional ventilation support.
Methods: In this retrospective cohort study, data were collected on extremely critical patients with COVID-19 from January 2020 to March 2020 in intensive care unit of a hospital in charge by national rescue team in Wuhan, China, the epicenter of pandemic. Patients were classified into the ECMO group and the conventional ventilation non-ECMO group. Clinical characteristics, technical characteristics, laboratory results, mortality, and complications of the two groups were analyzed.
Results: 88 patients with extremely critical COVID-19 were screened; 34 received ECMO support and 31 received conventional ventilation support. Both groups had comparable characteristics at baseline in terms of age, gender, and comorbidities. Before ECMO or conventional therapy, patients in the two groups had sever acute respiratory distress syndrome with a mean partial pressure of arterial oxygen to the fraction of inspired oxygen (PaO[SUB]2[/SUB] /FiO[SUB]2[/SUB] ) ratio of 69.6 and 75.4, respectively. At the time of reporting, patients in the ECMO had significantly lower in-hospital mortality compared with the control group (58.8 vs. 93.5%, p = .001).
Conclusion: ECMO is shown to decrease the mortality of extremely critical ill COVID-19 patients compared with the conventional treatment. Although complications occurred frequently, ECMO could still be a rescue therapy for the treatment of COVID-19 during the pandemic.
Keywords: COVID-19; ECMO; SARS-CoV-2.
. 2021 Jul 22.
doi: 10.1111/jocs.15833. Online ahead of print.
Extracorporeal membrane oxygenation (ECMO) for critically ill patients with coronavirus disease 2019 (COVID-19): A retrospective cohort study
Shuanglei Li[SUP] 1 [/SUP], Jing Xiong[SUP] 2 [/SUP], Zhongtao Du[SUP] 3 [/SUP], Wei Lai[SUP] 4 [/SUP], Xinhua Ma[SUP] 5 [/SUP], Zhichun Feng[SUP] 1 [/SUP], Yuan Shi[SUP] 2 [/SUP], Xiaoyang Hong[SUP] 1 [/SUP], Yundai Chen[SUP] 1 [/SUP]
Affiliations
- PMID: 34292632
- DOI: 10.1111/jocs.15833
Abstract
Purpose: The role of extracorporeal membrane oxygenatio (ECMO) for rescue therapy of respiratory failure in critically ill coronavirus disease 2019 (COVID-19) patients remains controversial. We aimed to evaluate the clinical outcomes of ECMO in the treatment of COVID-19 compared with conventional ventilation support.
Methods: In this retrospective cohort study, data were collected on extremely critical patients with COVID-19 from January 2020 to March 2020 in intensive care unit of a hospital in charge by national rescue team in Wuhan, China, the epicenter of pandemic. Patients were classified into the ECMO group and the conventional ventilation non-ECMO group. Clinical characteristics, technical characteristics, laboratory results, mortality, and complications of the two groups were analyzed.
Results: 88 patients with extremely critical COVID-19 were screened; 34 received ECMO support and 31 received conventional ventilation support. Both groups had comparable characteristics at baseline in terms of age, gender, and comorbidities. Before ECMO or conventional therapy, patients in the two groups had sever acute respiratory distress syndrome with a mean partial pressure of arterial oxygen to the fraction of inspired oxygen (PaO[SUB]2[/SUB] /FiO[SUB]2[/SUB] ) ratio of 69.6 and 75.4, respectively. At the time of reporting, patients in the ECMO had significantly lower in-hospital mortality compared with the control group (58.8 vs. 93.5%, p = .001).
Conclusion: ECMO is shown to decrease the mortality of extremely critical ill COVID-19 patients compared with the conventional treatment. Although complications occurred frequently, ECMO could still be a rescue therapy for the treatment of COVID-19 during the pandemic.
Keywords: COVID-19; ECMO; SARS-CoV-2.