tetano
Editor, Senior Moderator
J Am Acad Dermatol
. 2020 Jul 2;S0190-9622(20)32126-5.
doi: 10.1016/j.jaad.2020.06.1016. Online ahead of print.
The Spectrum of COVID-19-associated Dermatologic Manifestations: An International Registry of 716 Patients From 31 Countries
Esther E Freeman[SUP] 1 [/SUP], Devon E McMahon[SUP] 2 [/SUP], Jules B Lipoff[SUP] 3 [/SUP], Misha Rosenbach[SUP] 3 [/SUP], Carrie Kovarik[SUP] 3 [/SUP], Seemal R Desai[SUP] 4 [/SUP], Joanna Harp[SUP] 5 [/SUP], Junko Takeshita[SUP] 3 [/SUP], Lars E French[SUP] 6 [/SUP], Henry W Lim[SUP] 7 [/SUP], Bruce H Thiers[SUP] 8 [/SUP], George J Hruza[SUP] 9 [/SUP], Lindy P Fox[SUP] 10 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.
Objective: To characterize the diversity of cutaneous manifestations of COVID-19, and facilitate understanding of underlying pathophysiology.
Methods: Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies.
Results: The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. Of the 171 patients in the registry with laboratory-confirmed COVID-19, the most common morphologies were morbilliform (22%), pernio-like (18%), urticarial (16%), macular erythema (13%), vesicular (11%), papulosquamous (9.9%), and retiform purpura (6.4%). Pernio-like lesions were common in patients with mild disease, while retiform purpura presented exclusively in ill, hospitalized patients.
Limitations: We cannot estimate incidence or prevalence. Confirmation bias is possible.
Conclusion: This study highlights the array of cutaneous manifestations associated with COVID-19. Many morphologies were non-specific, while others may provide insight into potential immune or inflammatory pathways in COVID-19 pathophysiology.
Keywords: COVID toes; COVID-19; SARS-CoV-2; dermatology; global health; macular erythema; morbilliform; pernio; public health; registry; retiform purpura; urticarial; vesicular.
. 2020 Jul 2;S0190-9622(20)32126-5.
doi: 10.1016/j.jaad.2020.06.1016. Online ahead of print.
The Spectrum of COVID-19-associated Dermatologic Manifestations: An International Registry of 716 Patients From 31 Countries
Esther E Freeman[SUP] 1 [/SUP], Devon E McMahon[SUP] 2 [/SUP], Jules B Lipoff[SUP] 3 [/SUP], Misha Rosenbach[SUP] 3 [/SUP], Carrie Kovarik[SUP] 3 [/SUP], Seemal R Desai[SUP] 4 [/SUP], Joanna Harp[SUP] 5 [/SUP], Junko Takeshita[SUP] 3 [/SUP], Lars E French[SUP] 6 [/SUP], Henry W Lim[SUP] 7 [/SUP], Bruce H Thiers[SUP] 8 [/SUP], George J Hruza[SUP] 9 [/SUP], Lindy P Fox[SUP] 10 [/SUP]
Affiliations
- PMID: 32622888
- PMCID: PMC7331510
- DOI: 10.1016/j.jaad.2020.06.1016
Abstract
Background: Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.
Objective: To characterize the diversity of cutaneous manifestations of COVID-19, and facilitate understanding of underlying pathophysiology.
Methods: Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies.
Results: The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. Of the 171 patients in the registry with laboratory-confirmed COVID-19, the most common morphologies were morbilliform (22%), pernio-like (18%), urticarial (16%), macular erythema (13%), vesicular (11%), papulosquamous (9.9%), and retiform purpura (6.4%). Pernio-like lesions were common in patients with mild disease, while retiform purpura presented exclusively in ill, hospitalized patients.
Limitations: We cannot estimate incidence or prevalence. Confirmation bias is possible.
Conclusion: This study highlights the array of cutaneous manifestations associated with COVID-19. Many morphologies were non-specific, while others may provide insight into potential immune or inflammatory pathways in COVID-19 pathophysiology.
Keywords: COVID toes; COVID-19; SARS-CoV-2; dermatology; global health; macular erythema; morbilliform; pernio; public health; registry; retiform purpura; urticarial; vesicular.