tetano
Editor, Senior Moderator
J Allergy Clin Immunol Pract
. 2020 Nov 23;S2213-2198(20)31240-X.
doi: 10.1016/j.jaip.2020.11.020. Online ahead of print.
COVID-19 susceptibility in bronchial asthma
Ilan Green[SUP] 1 [/SUP], Eugene Merzon[SUP] 1 [/SUP], Shlomo Vinker[SUP] 1 [/SUP], Avivit Golan-Cohen[SUP] 1 [/SUP], Eli Magen[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Bronchial asthma has not been adequately assessed in the coronavirus disease 2019 (COVID-19). Respiratory allergy is associated with significant reductions in ACE2 receptors expression, which is the entry receptor for COVID-19.
Objective: To observe COVID-19 susceptibility in patients with bronchial asthma, we have analyzed the prevalence of asthma in a large cohort of consecutive outpatient subjects who tested in the RT-PCR assay for COVID-19.
Methods: This was a retrospective population-based cross-sectional study utilizing data from a large nation-wide health maintenance organization (HMO) in Israel. All HMO enrollees who had been tested for COVID-19 from February to June 2020 were included. Differences in demographic and clinical characteristics between the subjects with negative and positive COVID-19 RT-PCR tests and between COVID-19 RT-PCR positive subjects with and without asthma were analyzed.
Results: A total of 37,469 subjects were tested for COVID-19 RT-PCR and 2,266 (6.05 %) of them were positive. A significantly higher proportion of smokers was observed in the COVID-19 negative group, than in the COVID-19 positive group (4,734 (13.45 %) vs 103 (4.55 %); p<0.001). Asthma was found in 153 (6.75 %) subjects of COVID-19 positive and in 3,388 (9.62 %) subjects of COVID-19 negative group (p<0.001). No significant impact of antileukotrienes, inhaled corticosteroids and long-acting beta-blockers use was revealed on COVID-19 positivity proportions. Multiple logistic regression analysis adjusted for sex, age, smoking, and comorbidity revealed a negative association of asthma with the likelihood of being positive for COVID-19 (OR 0.71 (95% confidence interval, 0.58-0.87); p=0.001).
Conclusion: we observed lower COVID-19 susceptibility in patients with pre-existing asthma.
Keywords: COVID-19; asthma; smoking; susceptibility.
. 2020 Nov 23;S2213-2198(20)31240-X.
doi: 10.1016/j.jaip.2020.11.020. Online ahead of print.
COVID-19 susceptibility in bronchial asthma
Ilan Green[SUP] 1 [/SUP], Eugene Merzon[SUP] 1 [/SUP], Shlomo Vinker[SUP] 1 [/SUP], Avivit Golan-Cohen[SUP] 1 [/SUP], Eli Magen[SUP] 2 [/SUP]
Affiliations
- PMID: 33242628
- PMCID: PMC7683297
- DOI: 10.1016/j.jaip.2020.11.020
Abstract
Background: Bronchial asthma has not been adequately assessed in the coronavirus disease 2019 (COVID-19). Respiratory allergy is associated with significant reductions in ACE2 receptors expression, which is the entry receptor for COVID-19.
Objective: To observe COVID-19 susceptibility in patients with bronchial asthma, we have analyzed the prevalence of asthma in a large cohort of consecutive outpatient subjects who tested in the RT-PCR assay for COVID-19.
Methods: This was a retrospective population-based cross-sectional study utilizing data from a large nation-wide health maintenance organization (HMO) in Israel. All HMO enrollees who had been tested for COVID-19 from February to June 2020 were included. Differences in demographic and clinical characteristics between the subjects with negative and positive COVID-19 RT-PCR tests and between COVID-19 RT-PCR positive subjects with and without asthma were analyzed.
Results: A total of 37,469 subjects were tested for COVID-19 RT-PCR and 2,266 (6.05 %) of them were positive. A significantly higher proportion of smokers was observed in the COVID-19 negative group, than in the COVID-19 positive group (4,734 (13.45 %) vs 103 (4.55 %); p<0.001). Asthma was found in 153 (6.75 %) subjects of COVID-19 positive and in 3,388 (9.62 %) subjects of COVID-19 negative group (p<0.001). No significant impact of antileukotrienes, inhaled corticosteroids and long-acting beta-blockers use was revealed on COVID-19 positivity proportions. Multiple logistic regression analysis adjusted for sex, age, smoking, and comorbidity revealed a negative association of asthma with the likelihood of being positive for COVID-19 (OR 0.71 (95% confidence interval, 0.58-0.87); p=0.001).
Conclusion: we observed lower COVID-19 susceptibility in patients with pre-existing asthma.
Keywords: COVID-19; asthma; smoking; susceptibility.