‘It’s inconceivable’: 5 family members in critical condition from COVID-19 after relative dies

[Shiloh]

Source: https://www.nj.com/coronavirus/2020...dition-from-covid-19-after-relative-dies.html

‘It’s inconceivable’: 5 family members in critical condition from COVID-19 after relative dies
Updated Mar 18, 2020; Posted Mar 17, 2020
By Spencer Kent | NJ Advance Media for NJ.com

UPDATE: Carmine Fusco, Rita Fusco-Jackson’s brother, died Wednesday.

Five members of the same New Jersey family lay in hospital beds at a Freehold medical facility, each infected with the coronavirus.

And a sixth remains in a Pennsylvania hospital battling the same virus.

Nearly all are in critical condition.

The six are family members of Rita Fusco-Jackson, the 55-year-old woman who died last Friday and later tested positive for COVID-19, according to her sister, Elizabeth Fusco...

 

[Pathfinder]

Coronavirus Ravages 7 Members of a Single Family, Killing 3
...
By Tracey Tully
Published March 18, 2020
Updated March 19, 2020, 8:52 a.m. ET
...
Mrs. Fusco, 73, died on Wednesday night after contracting the coronavirus — hours after her son died from the virus and five days after her daughter’s death, a relative said.

Four other children who contracted coronavirus remain hospitalized, three of them in critical condition, the relative, Roseann Paradiso Fodera, said.
...
https://www.nytimes.com/2020/03/18/nyregion/new-jersey-family-coronavirus.html

 

[bertrand789]

Plusieurs articles abordent des sensibilit?s g?n?tiques, dont par exemple le groupe sanguin. Il y a un lieu ou l'on recueille l'ensemble des faits et ou l'on met un peu d'ordre ? je connais ces lieux chez les animaux, mais pas chez l'homme, d'ou ma question ?

 

[blacknail]

Plusieurs articles abordent des sensibilit?s g?n?tiques, dont par exemple le groupe sanguin. Il y a un lieu ou l'on recueille l'ensemble des faits et ou l'on met un peu d'ordre ? je connais ces lieux chez les animaux, mais pas chez l'homme, d'ou ma question ?

It is interesting that this is an Italian family and this virus is hitting Italy the hardest at the moment. It could be that being of Italian descent is a risk factor that should be investigated further if more cases like this emerge.

 

[bertrand789]

Les chinois l'ont fait et publi?, eux. Les autres vont se mettre au boulot quand ?
par ce que, pour le moment, en France, j'ai l'impression que c'est plus du brassage de vent ...

 

[Nika]

It is interesting that this is an Italian family and this virus is hitting Italy the hardest at the moment. It could be that being of Italian descent is a risk factor that should be investigated further if more cases like this emerge.

See this paper for some discussion/analysis of differences between the three highest profile coronavirus strains (SARS[-1], MERS, SARS-CoV-2). As mentioned therein, pathogenicity is a multifactorial phenotypic character. It will be interesting to see the sequence from this NJ cluster.

"Abstract: the recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 and causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus."

https://www.biorxiv.org/content/10.1...925v1.full.pdf

 

[Nika]

It is interesting that this is an Italian family and this virus is hitting Italy the hardest at the moment. It could be that being of Italian descent is a risk factor that should be investigated further if more cases like this emerge.

Ive scanned this phylogenetic resource (that everyone should spend some time with) and do not see any data on the NJ cluster (could of missed it, have a bit of a migraine today)

https://nextstrain.org/ncov

 

[Emily]

Hope you are feeling better soon, Nika!

 

[Nika]

thnx Emily! Been raking/cleaning up my garden beds and that kicked up a load of allergens, for sure.