Treyfish
Moderator
Published by Web editing
18/10/2009
Lanalisi genome dellOvest Nile virus (West Nile virus) isolated from a patient Veneto explains the mechanism by which the virus resurfaced in Italy spreading rapidly in several regions.
Dallagosto of 2008 in Italy have been reported 24 cases of encephalitis from West Nile virus, 11 of which were identified in the province of Rovigo. The West Nile virus, which belongs to the family Flaviviridae, was isolated for the first time in 1937 in Uganda, the West Nile district, which takes its name. The West Nile virus causes no symptoms in most infected subjects.
Among symptomatic cases, approximately 20% have mild symptoms: fever, headache, nausea, vomiting, swollen lymph glands, rash. In elderly and debilitated, however, the symptoms can 'be more' serious and include high fever, neurological disorders, up to paralysis and coma.
In the laboratory of Virology dellAzienda Hospital of Padua, directed by Prof. George Pal, where they performed the tests for the diagnosis dinfezione from West Nile virus for all suspected cases of the Veneto Region, was recently isolated the virus for the first time in Italy from a blood donor is not suffering from disease.
This has allowed the complete sequence of the viral genome and compare it with the virus strain isolated in Tuscany in 1998, during unepidemia occurred in horses, and with the genome of other viruses isolated in Europe and the United States of America.
This study showed that the new strain of West Nile virus is circulating in Italy is very similar to the one isolated in 1998, but has acquired new mutations that confer increased virulence and ability 'spread. In particular, the mutation was observed in dellaminoacido threonine proline in viral polymerase, which makes it more 'stable protein under conditions of high temperature, which the body temperature of birds, which are the natural reservoir of West Nile virus. This mutation, which was also observed in the U.S. and virus strain was associated with increased virulence in the American crow, was held responsible for the rapid spread of the virus from east to west.
The presence of this variant more 'virulent virus, along with environmental conditions favorable for the propagation of the virus (climate, mosquito vector, reservoir animal) may increase the risk of spreading West Nile virus in our area and dinfezione human cases, as already occurring recently in the USA. Sara 'therefore critical lattivit warning of new cases of infection and for monitoring the spread of the virus, screening of donated blood and organs and preventing the spread of vectors. important that these activities' are carried out by highly qualified specialists as virologists.:tiphat:http://www.padovanews.it/index.php?option=com_content&task=view&id=61006&Itemid=112
18/10/2009
Lanalisi genome dellOvest Nile virus (West Nile virus) isolated from a patient Veneto explains the mechanism by which the virus resurfaced in Italy spreading rapidly in several regions.
Dallagosto of 2008 in Italy have been reported 24 cases of encephalitis from West Nile virus, 11 of which were identified in the province of Rovigo. The West Nile virus, which belongs to the family Flaviviridae, was isolated for the first time in 1937 in Uganda, the West Nile district, which takes its name. The West Nile virus causes no symptoms in most infected subjects.
Among symptomatic cases, approximately 20% have mild symptoms: fever, headache, nausea, vomiting, swollen lymph glands, rash. In elderly and debilitated, however, the symptoms can 'be more' serious and include high fever, neurological disorders, up to paralysis and coma.
In the laboratory of Virology dellAzienda Hospital of Padua, directed by Prof. George Pal, where they performed the tests for the diagnosis dinfezione from West Nile virus for all suspected cases of the Veneto Region, was recently isolated the virus for the first time in Italy from a blood donor is not suffering from disease.
This has allowed the complete sequence of the viral genome and compare it with the virus strain isolated in Tuscany in 1998, during unepidemia occurred in horses, and with the genome of other viruses isolated in Europe and the United States of America.
This study showed that the new strain of West Nile virus is circulating in Italy is very similar to the one isolated in 1998, but has acquired new mutations that confer increased virulence and ability 'spread. In particular, the mutation was observed in dellaminoacido threonine proline in viral polymerase, which makes it more 'stable protein under conditions of high temperature, which the body temperature of birds, which are the natural reservoir of West Nile virus. This mutation, which was also observed in the U.S. and virus strain was associated with increased virulence in the American crow, was held responsible for the rapid spread of the virus from east to west.
The presence of this variant more 'virulent virus, along with environmental conditions favorable for the propagation of the virus (climate, mosquito vector, reservoir animal) may increase the risk of spreading West Nile virus in our area and dinfezione human cases, as already occurring recently in the USA. Sara 'therefore critical lattivit warning of new cases of infection and for monitoring the spread of the virus, screening of donated blood and organs and preventing the spread of vectors. important that these activities' are carried out by highly qualified specialists as virologists.:tiphat:http://www.padovanews.it/index.php?option=com_content&task=view&id=61006&Itemid=112