tetano
Editor, Senior Moderator
iScience
. 2020 Sep 29;101631.
doi: 10.1016/j.isci.2020.101631. Online ahead of print.
Mitochondria - in the crossfire of SARS-CoV-2 and immunity
Johannes Burtscher[SUP] 1 2 [/SUP], Giuseppe Cappellano[SUP] 3 4 [/SUP], Akiko Omori[SUP] 5 6 [/SUP], Takumi Koshiba[SUP] 7 [/SUP], Gr?goire P Millet[SUP] 2 [/SUP]
Affiliations
Abstract
The pathophysiology, immune reaction, differential vulnerability of different population groups and viral host immune system evasion strategies of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection are not yet well understood. Here, we reviewed the multitude of known strategies of coronaviruses and other viruses to usurp mitochondria-associated mechanisms involved in the host innate immune response and put them in context with the current knowledge on SARS-CoV-2. We argue that maintenance of mitochondrial integrity is essential for adequate innate immune system responses and to blunt mitochondrial modulation by SARS-CoV-2. Mitochondrial health thus may determine differential vulnerabilities to SARS-CoV-2 infection rendering markers of mitochondrial functions promising potential biomarkers for SARS-CoV-2 infection risk and severity of outcome. Current knowledge gaps on our understanding of mitochondrial involvement in SARS-CoV-2 infection, life-style and pharmacological strategies to improve mitochondrial integrity and potential reciprocal interactions with chronic and age-related diseases, e.g. Parkinson's Disease, are pointed out.
. 2020 Sep 29;101631.
doi: 10.1016/j.isci.2020.101631. Online ahead of print.
Mitochondria - in the crossfire of SARS-CoV-2 and immunity
Johannes Burtscher[SUP] 1 2 [/SUP], Giuseppe Cappellano[SUP] 3 4 [/SUP], Akiko Omori[SUP] 5 6 [/SUP], Takumi Koshiba[SUP] 7 [/SUP], Gr?goire P Millet[SUP] 2 [/SUP]
Affiliations
- PMID: 33015593
- PMCID: PMC7524535
- DOI: 10.1016/j.isci.2020.101631
Abstract
The pathophysiology, immune reaction, differential vulnerability of different population groups and viral host immune system evasion strategies of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection are not yet well understood. Here, we reviewed the multitude of known strategies of coronaviruses and other viruses to usurp mitochondria-associated mechanisms involved in the host innate immune response and put them in context with the current knowledge on SARS-CoV-2. We argue that maintenance of mitochondrial integrity is essential for adequate innate immune system responses and to blunt mitochondrial modulation by SARS-CoV-2. Mitochondrial health thus may determine differential vulnerabilities to SARS-CoV-2 infection rendering markers of mitochondrial functions promising potential biomarkers for SARS-CoV-2 infection risk and severity of outcome. Current knowledge gaps on our understanding of mitochondrial involvement in SARS-CoV-2 infection, life-style and pharmacological strategies to improve mitochondrial integrity and potential reciprocal interactions with chronic and age-related diseases, e.g. Parkinson's Disease, are pointed out.