tetano
Editor, Senior Moderator
iScience
. 2024 Oct 11;27(11):111166.
doi: 10.1016/j.isci.2024.111166. eCollection 2024 Nov 15. High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
Marcus Z W Tong[SUP] 1 [/SUP], Katina D Hulme[SUP] 1 2 [/SUP], Soi Cheng Law[SUP] 3 [/SUP], Ellesandra Noye[SUP] 1 [/SUP], Emily S Dorey[SUP] 3 [/SUP], Keng Yih Chew[SUP] 1 [/SUP], Louise C Rowntree[SUP] 4 [/SUP], Carolien E van de Sandt[SUP] 4 5 [/SUP], Katherine Kedzierska[SUP] 4 [/SUP], Marco Goeijenbier[SUP] 6 7 [/SUP], Katharina Ronacher[SUP] 3 8 [/SUP], Fawaz Alzaid[SUP] 9 10 [/SUP], Jean-Baptiste Julla[SUP] 9 11 [/SUP], Jean-Pierre Riveline[SUP] 9 11 [/SUP], Katie E Lineburg[SUP] 12 [/SUP], Corey Smith[SUP] 12 13 [/SUP], Emma J Grant[SUP] 14 15 [/SUP], Stephanie Gras[SUP] 14 15 [/SUP], Linda A Gallo[SUP] 16 [/SUP], Helen L Barrett[SUP] 3 17 18 [/SUP], Kirsty R Short[SUP] 1 8 13 [/SUP]
Affiliations
Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8[SUP]+[/SUP]CD107a[SUP]-[/SUP]IFNγ[SUP]-[/SUP]MIP1β[SUP]-[/SUP]TNF[SUP]+[/SUP] T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.
Keywords: Endocrinology; Human metabolism.
. 2024 Oct 11;27(11):111166.
doi: 10.1016/j.isci.2024.111166. eCollection 2024 Nov 15. High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
Marcus Z W Tong[SUP] 1 [/SUP], Katina D Hulme[SUP] 1 2 [/SUP], Soi Cheng Law[SUP] 3 [/SUP], Ellesandra Noye[SUP] 1 [/SUP], Emily S Dorey[SUP] 3 [/SUP], Keng Yih Chew[SUP] 1 [/SUP], Louise C Rowntree[SUP] 4 [/SUP], Carolien E van de Sandt[SUP] 4 5 [/SUP], Katherine Kedzierska[SUP] 4 [/SUP], Marco Goeijenbier[SUP] 6 7 [/SUP], Katharina Ronacher[SUP] 3 8 [/SUP], Fawaz Alzaid[SUP] 9 10 [/SUP], Jean-Baptiste Julla[SUP] 9 11 [/SUP], Jean-Pierre Riveline[SUP] 9 11 [/SUP], Katie E Lineburg[SUP] 12 [/SUP], Corey Smith[SUP] 12 13 [/SUP], Emma J Grant[SUP] 14 15 [/SUP], Stephanie Gras[SUP] 14 15 [/SUP], Linda A Gallo[SUP] 16 [/SUP], Helen L Barrett[SUP] 3 17 18 [/SUP], Kirsty R Short[SUP] 1 8 13 [/SUP]
Affiliations
- PMID: 39524368
- PMCID: PMC11550119
- DOI: 10.1016/j.isci.2024.111166
Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8[SUP]+[/SUP]CD107a[SUP]-[/SUP]IFNγ[SUP]-[/SUP]MIP1β[SUP]-[/SUP]TNF[SUP]+[/SUP] T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.
Keywords: Endocrinology; Human metabolism.