tetano
Editor, Senior Moderator
iScience
. 2025 Sep 4;28(10):113502.
doi: 10.1016/j.isci.2025.113502. eCollection 2025 Oct 17. Clostridium butyricum-altered lung microbiome is associated with enhanced anti-influenza effects via G-protein-coupled receptor120
Mao Hagihara[SUP] 1 2 [/SUP], Makoto Yamashita[SUP] 2 [/SUP], Tadashi Ariyoshi[SUP] 2 3 [/SUP], Ayaka Minemura[SUP] 3 [/SUP], Chika Yoshida[SUP] 3 [/SUP], Seiya Higashi[SUP] 3 [/SUP], Kentaro Oka[SUP] 3 [/SUP], Motomichi Takahashi[SUP] 3 [/SUP], Akinobu Ota[SUP] 4 [/SUP], Akihiro Maenaka[SUP] 5 [/SUP], Kenta Iwasaki[SUP] 5 [/SUP], Jun Hirai[SUP] 1 [/SUP], Yuichi Shibata[SUP] 2 [/SUP], Takumi Umemura[SUP] 2 [/SUP], Takeshi Mori[SUP] 2 [/SUP], Hideo Kato[SUP] 2 6 [/SUP], Nobuhiro Asai[SUP] 2 [/SUP], Hiroshige Mikamo[SUP] 2 [/SUP]
Affiliations
We previously reported that orally administered Clostridium butyricum enhances anti-influenza virus effects through the interferon-λ upregulation in mice lungs; however, the precise mechanism remains unclear. Orally administered C. butyricum promotes the proliferation of Bifidobacterium species in the lung microbiome, and this enhances C. butyricum induced anti-influenza effects. Among the Bifidobacterium species, B. longum effectively enhanced the sensitivity of the lung epithelial cells to long-chain fatty acids through the G-protein-coupled receptor120 upregulation. Oral administration of C. butyricum altered long-chain fatty acid metabolism and promoted interferon-λ production through G-protein-coupled receptor120. We hypothesized that these effects enhance anti-influenza virus responses through interferon-λ upregulation via collaboration between long-chain fatty acid metabolism alterations and the lung microbiome moderation. This study identified a gut-lung axis mechanism and provides insights into viral respiratory infection treatment and prophylaxis.
Keywords: Cell biology; Microbiology.
. 2025 Sep 4;28(10):113502.
doi: 10.1016/j.isci.2025.113502. eCollection 2025 Oct 17. Clostridium butyricum-altered lung microbiome is associated with enhanced anti-influenza effects via G-protein-coupled receptor120
Mao Hagihara[SUP] 1 2 [/SUP], Makoto Yamashita[SUP] 2 [/SUP], Tadashi Ariyoshi[SUP] 2 3 [/SUP], Ayaka Minemura[SUP] 3 [/SUP], Chika Yoshida[SUP] 3 [/SUP], Seiya Higashi[SUP] 3 [/SUP], Kentaro Oka[SUP] 3 [/SUP], Motomichi Takahashi[SUP] 3 [/SUP], Akinobu Ota[SUP] 4 [/SUP], Akihiro Maenaka[SUP] 5 [/SUP], Kenta Iwasaki[SUP] 5 [/SUP], Jun Hirai[SUP] 1 [/SUP], Yuichi Shibata[SUP] 2 [/SUP], Takumi Umemura[SUP] 2 [/SUP], Takeshi Mori[SUP] 2 [/SUP], Hideo Kato[SUP] 2 6 [/SUP], Nobuhiro Asai[SUP] 2 [/SUP], Hiroshige Mikamo[SUP] 2 [/SUP]
Affiliations
- PMID: 41035679
- PMCID: PMC12483594
- DOI: 10.1016/j.isci.2025.113502
We previously reported that orally administered Clostridium butyricum enhances anti-influenza virus effects through the interferon-λ upregulation in mice lungs; however, the precise mechanism remains unclear. Orally administered C. butyricum promotes the proliferation of Bifidobacterium species in the lung microbiome, and this enhances C. butyricum induced anti-influenza effects. Among the Bifidobacterium species, B. longum effectively enhanced the sensitivity of the lung epithelial cells to long-chain fatty acids through the G-protein-coupled receptor120 upregulation. Oral administration of C. butyricum altered long-chain fatty acid metabolism and promoted interferon-λ production through G-protein-coupled receptor120. We hypothesized that these effects enhance anti-influenza virus responses through interferon-λ upregulation via collaboration between long-chain fatty acid metabolism alterations and the lung microbiome moderation. This study identified a gut-lung axis mechanism and provides insights into viral respiratory infection treatment and prophylaxis.
Keywords: Cell biology; Microbiology.