tetano
Editor, Senior Moderator
ISA Trans
. 2020 Sep 28;S0019-0578(20)30389-X.
doi: 10.1016/j.isatra.2020.09.015. Online ahead of print.
Mitigating the transmission of infection and death due to SARS-CoV-2 through non-pharmaceutical interventions and repurposing drugs
Chittaranjan Mondal[SUP] 1 [/SUP], Debadatta Adak[SUP] 2 [/SUP], Abhijit Majumder[SUP] 1 [/SUP], Nandadulal Bairagi[SUP] 3 [/SUP]
Affiliations
Abstract
The Covid-19 pandemic has put the world under immeasurable stress. There is no specific drug or vaccine till now that can cure the infection or protect people from the infection of coronavirus. It is therefore prudent to use the existing resources and control strategies in an optimal way to contain the virus spread and provide the best possible treatments to the infected individuals. Use of the repurposing drugs along with the non-pharmaceutical intervention strategies may be the right way for fighting against the ongoing pandemic. It is the objective of this work to demonstrate through mathematical modelling and analysis how and to what extent such control strategies can improve the overall Covid-19 epidemic burden. The criteria for disease elimination & persistence were established through the basic reproduction number. A case study with the Indian Covid-19 epidemic data is presented to visualize and illustrate the effects of lockdown, maintaining personal hygiene & safe distancing, and repurposing drugs. It is shown that India can significantly improve the overall Covid-19 epidemic burden through the combined use of NPIs and repurposing drugs though containment of spreading is difficult without serious community participation.
Keywords: Basic reproduction number; Control strategy; Data fitting; Local & global stability; Mathematical model for Covid-19.
. 2020 Sep 28;S0019-0578(20)30389-X.
doi: 10.1016/j.isatra.2020.09.015. Online ahead of print.
Mitigating the transmission of infection and death due to SARS-CoV-2 through non-pharmaceutical interventions and repurposing drugs
Chittaranjan Mondal[SUP] 1 [/SUP], Debadatta Adak[SUP] 2 [/SUP], Abhijit Majumder[SUP] 1 [/SUP], Nandadulal Bairagi[SUP] 3 [/SUP]
Affiliations
- PMID: 33070984
- PMCID: PMC7521443
- DOI: 10.1016/j.isatra.2020.09.015
Abstract
The Covid-19 pandemic has put the world under immeasurable stress. There is no specific drug or vaccine till now that can cure the infection or protect people from the infection of coronavirus. It is therefore prudent to use the existing resources and control strategies in an optimal way to contain the virus spread and provide the best possible treatments to the infected individuals. Use of the repurposing drugs along with the non-pharmaceutical intervention strategies may be the right way for fighting against the ongoing pandemic. It is the objective of this work to demonstrate through mathematical modelling and analysis how and to what extent such control strategies can improve the overall Covid-19 epidemic burden. The criteria for disease elimination & persistence were established through the basic reproduction number. A case study with the Indian Covid-19 epidemic data is presented to visualize and illustrate the effects of lockdown, maintaining personal hygiene & safe distancing, and repurposing drugs. It is shown that India can significantly improve the overall Covid-19 epidemic burden through the combined use of NPIs and repurposing drugs though containment of spreading is difficult without serious community participation.
Keywords: Basic reproduction number; Control strategy; Data fitting; Local & global stability; Mathematical model for Covid-19.