Mary Wilson
Well-known member
7 Feb 2023
DOI: 10.1126/sciimmunol.adg73
SHIV PILLAI
Abstract
Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and NK cell–dependent elimination of infected cells.
https://www.science.org/doi/10.1126/sciimmunol.adg7327
DOI: 10.1126/sciimmunol.adg73
SHIV PILLAI
Abstract
Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and NK cell–dependent elimination of infected cells.
https://www.science.org/doi/10.1126/sciimmunol.adg7327