tetano
Editor, Senior Moderator
Hum Immunol. 2011 May 3. [Epub ahead of print]
Involvement of type I immune responses in swine-origin H1N1 influenza virus infection.
Frisullo G, Iorio R, Plantone D, Nociti V, Patanella AK, Marti A, Palermo C, Valentini P, Mariotti P, Batocchi AP.
Source
Institute of Neurology, Department of Neurosciences, Catholic University, Rome, Italy.
Abstract
Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1 with acute necrotizing encephalitis, 2 with pneumonia, and 2 without complications), 5 children with seasonal influenza, and 5 healthy children. We found higher percentages of T-bet(+) CD4(+)CD8(+) T cells, monocytes, and B cells, granzyme B(+) and perforin(+) CD4(+), and CD8(+) T cells in affected children with both seasonal and H1N1 influenza than in controls, whereas both groups demonstrated similar percentages of CD4(+)CD25(+)Foxp3(+) regulatory T cells. In infected children with complications we observed high percentages of perforin(+) and interferon-γ(+) CD4(+) and CD8(+) T cells associated with low percentages of T regulatory cells. Our data suggest a dysregulation of antipathogen type I immune responses in complicated S-OIV infections.
Copyright ? 2011. Published by Elsevier Inc.
PMID:
21571020
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21571020
Involvement of type I immune responses in swine-origin H1N1 influenza virus infection.
Frisullo G, Iorio R, Plantone D, Nociti V, Patanella AK, Marti A, Palermo C, Valentini P, Mariotti P, Batocchi AP.
Source
Institute of Neurology, Department of Neurosciences, Catholic University, Rome, Italy.
Abstract
Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1 with acute necrotizing encephalitis, 2 with pneumonia, and 2 without complications), 5 children with seasonal influenza, and 5 healthy children. We found higher percentages of T-bet(+) CD4(+)CD8(+) T cells, monocytes, and B cells, granzyme B(+) and perforin(+) CD4(+), and CD8(+) T cells in affected children with both seasonal and H1N1 influenza than in controls, whereas both groups demonstrated similar percentages of CD4(+)CD25(+)Foxp3(+) regulatory T cells. In infected children with complications we observed high percentages of perforin(+) and interferon-γ(+) CD4(+) and CD8(+) T cells associated with low percentages of T regulatory cells. Our data suggest a dysregulation of antipathogen type I immune responses in complicated S-OIV infections.
Copyright ? 2011. Published by Elsevier Inc.
PMID:
21571020
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21571020