tetano
Editor, Senior Moderator
Virus Genes. 2019 Aug 19. doi: 10.1007/s11262-019-01700-z. [Epub ahead of print]
[h=1]Inventory of molecular markers affecting biological characteristics of avian influenza A viruses.[/h] Suttie A[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Deng YM[SUP]3[/SUP], Greenhill AR[SUP]2[/SUP], Dussart P[SUP]1[/SUP], Horwood PF[SUP]4[/SUP], Karlsson EA[SUP]5[/SUP].
[h=3]Author information[/h] 1 Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, 5 Monivong Blvd, PO Box #983, Phnom Penh, Cambodia. 2 School of Health and Life Sciences, Federation University, Churchill, Australia. 3 World Health Organization Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. 4 College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD, Australia. 5 Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, 5 Monivong Blvd, PO Box #983, Phnom Penh, Cambodia. ekarlsson@pasteur-kh.org.
[h=3]Abstract[/h] Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human infection; however, AIVs are still a high risk as future pandemic strains, especially if they acquire further mutations that facilitate human infection and/or increase pathogenesis. Molecular characterization of sequencing data for known genetic markers associated with AIV adaptation, transmission, and antiviral resistance allows for fast, efficient assessment of AIV risk. Here we summarize and update the current knowledge on experimentally verified molecular markers involved in AIV pathogenicity, receptor binding, replicative capacity, and transmission in both poultry and mammals with a broad focus to include data available on other AIV subtypes outside of A/H5N1 and A/H7N9.
[h=4]KEYWORDS:[/h] Avian influenza; Influenza virus; Molecular inventory; Molecular marker; Mutation; Risk assessment
PMID: 31428925 DOI: 10.1007/s11262-019-01700-z
[h=1]Inventory of molecular markers affecting biological characteristics of avian influenza A viruses.[/h] Suttie A[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Deng YM[SUP]3[/SUP], Greenhill AR[SUP]2[/SUP], Dussart P[SUP]1[/SUP], Horwood PF[SUP]4[/SUP], Karlsson EA[SUP]5[/SUP].
[h=3]Author information[/h] 1 Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, 5 Monivong Blvd, PO Box #983, Phnom Penh, Cambodia. 2 School of Health and Life Sciences, Federation University, Churchill, Australia. 3 World Health Organization Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. 4 College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD, Australia. 5 Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, 5 Monivong Blvd, PO Box #983, Phnom Penh, Cambodia. ekarlsson@pasteur-kh.org.
[h=3]Abstract[/h] Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human infection; however, AIVs are still a high risk as future pandemic strains, especially if they acquire further mutations that facilitate human infection and/or increase pathogenesis. Molecular characterization of sequencing data for known genetic markers associated with AIV adaptation, transmission, and antiviral resistance allows for fast, efficient assessment of AIV risk. Here we summarize and update the current knowledge on experimentally verified molecular markers involved in AIV pathogenicity, receptor binding, replicative capacity, and transmission in both poultry and mammals with a broad focus to include data available on other AIV subtypes outside of A/H5N1 and A/H7N9.
[h=4]KEYWORDS:[/h] Avian influenza; Influenza virus; Molecular inventory; Molecular marker; Mutation; Risk assessment
PMID: 31428925 DOI: 10.1007/s11262-019-01700-z