tetano
Editor, Senior Moderator
J Pharmacol Sci. 2016 Apr 22. pii: S1347-8613(16)30035-4. doi: 10.1016/j.jphs.2016.04.018. [Epub ahead of print]
[h=1]Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay.[/h] Nakamura Y[SUP]1[/SUP], Sasaki R[SUP]2[/SUP], Cao X[SUP]1[/SUP], Wada T[SUP]1[/SUP], Hamaguchi S[SUP]2[/SUP], Izumi-Nakaseko H[SUP]1[/SUP], Ando K[SUP]1[/SUP], Tanaka H[SUP]2[/SUP], Takahara A[SUP]3[/SUP], Sugiyama A[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir in doses of 3-30 mg/kg, i.v. did not induce torsade de pointes in the canine model, whereas that in concentrations of 30-300 μM decreased maximum rate of phase 0 depolarization, shortened action potential duration at 30%, 60% and 90% repolarization levels, but prolonged difference in action-potential duration between 30% and 90% repolarization levels in a concentration-related manner. These results indicate that oseltamivir will not induce torsade de pointes clinically, since it inhibits both inward and outward currents.
Copyright ? 2016 The Authors. Production and hosting by Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Intravenous; Oseltamivir; Torsade de pointes
PMID: 27174864 [PubMed - as supplied by publisher] Free full text
[h=1]Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay.[/h] Nakamura Y[SUP]1[/SUP], Sasaki R[SUP]2[/SUP], Cao X[SUP]1[/SUP], Wada T[SUP]1[/SUP], Hamaguchi S[SUP]2[/SUP], Izumi-Nakaseko H[SUP]1[/SUP], Ando K[SUP]1[/SUP], Tanaka H[SUP]2[/SUP], Takahara A[SUP]3[/SUP], Sugiyama A[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir in doses of 3-30 mg/kg, i.v. did not induce torsade de pointes in the canine model, whereas that in concentrations of 30-300 μM decreased maximum rate of phase 0 depolarization, shortened action potential duration at 30%, 60% and 90% repolarization levels, but prolonged difference in action-potential duration between 30% and 90% repolarization levels in a concentration-related manner. These results indicate that oseltamivir will not induce torsade de pointes clinically, since it inhibits both inward and outward currents.
Copyright ? 2016 The Authors. Production and hosting by Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Intravenous; Oseltamivir; Torsade de pointes
PMID: 27174864 [PubMed - as supplied by publisher] Free full text