tetano
Editor, Senior Moderator
J Infect Chemother. 2012 Jun 2. [Epub ahead of print]
Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient.
Hamada N, Imamura Y, Hara K, Kashiwagi T, Imamura Y, Nakazono Y, Chijiwa K, Watanabe H.
Source
Division of Infectious Disease, Department of Infectious Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan, nhamada@med.kurume-u.ac.jp.
Abstract
The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term administration of oseltamivir. Intrahost variation of the virus showed that the H275Y mutant virus was the predominant population in both nasopharynx and right lung, whereas the oseltamivir-sensitive virus comprised half the population in the left lung. By constructing minimum spanning trees, it is proposed that the H275Y mutant might be generated primarily in the nasopharynx, then spread to the right and left lungs.
PMID:
22661221
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22661221
Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient.
Hamada N, Imamura Y, Hara K, Kashiwagi T, Imamura Y, Nakazono Y, Chijiwa K, Watanabe H.
Source
Division of Infectious Disease, Department of Infectious Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan, nhamada@med.kurume-u.ac.jp.
Abstract
The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term administration of oseltamivir. Intrahost variation of the virus showed that the H275Y mutant virus was the predominant population in both nasopharynx and right lung, whereas the oseltamivir-sensitive virus comprised half the population in the left lung. By constructing minimum spanning trees, it is proposed that the H275Y mutant might be generated primarily in the nasopharynx, then spread to the right and left lungs.
PMID:
22661221
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22661221