tetano
Editor, Senior Moderator
Intern Med
. 2021 Dec 11.
doi: 10.2169/internalmedicine.8747-21. Online ahead of print.
A Case of Refractory Longitudinally Extensive Transverse Myelitis after Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in a Japanese Man
Noriyuki Miyaue[SUP] 1 [/SUP], Akira Yoshida[SUP] 1 [/SUP], Yuki Yamanishi[SUP] 1 [/SUP], Satoshi Tada[SUP] 1 [/SUP], Rina Ando[SUP] 1 [/SUP], Yuko Hosokawa[SUP] 2 [/SUP], Hayato Yabe[SUP] 2 [/SUP], Masahiro Nagai[SUP] 1 [/SUP]
Affiliations
Abstract
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered worldwide. There have been reports of neurological adverse events following immunization (AEFIs). We herein report a case of refractory longitudinally extensive transverse myelitis in a 75-year-old Japanese man following the first dose of the BNT162b2 vaccine. The patient developed total sensory loss below the umbilicus and complete paralysis in both legs. Although he was treated with steroid therapy and plasma exchange, his recovery was limited, and severe sequelae remained. Further studies, including large epidemiological studies, are required to understand the association between SARS-CoV-2 vaccines and neurological AEFI.
Keywords: COVID-19; SARS-CoV-2; adverse event following immunization; longitudinally extensive transverse myelitis; transverse myelitis; vaccine.
. 2021 Dec 11.
doi: 10.2169/internalmedicine.8747-21. Online ahead of print.
A Case of Refractory Longitudinally Extensive Transverse Myelitis after Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in a Japanese Man
Noriyuki Miyaue[SUP] 1 [/SUP], Akira Yoshida[SUP] 1 [/SUP], Yuki Yamanishi[SUP] 1 [/SUP], Satoshi Tada[SUP] 1 [/SUP], Rina Ando[SUP] 1 [/SUP], Yuko Hosokawa[SUP] 2 [/SUP], Hayato Yabe[SUP] 2 [/SUP], Masahiro Nagai[SUP] 1 [/SUP]
Affiliations
- PMID: 34897155
- DOI: 10.2169/internalmedicine.8747-21
Abstract
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered worldwide. There have been reports of neurological adverse events following immunization (AEFIs). We herein report a case of refractory longitudinally extensive transverse myelitis in a 75-year-old Japanese man following the first dose of the BNT162b2 vaccine. The patient developed total sensory loss below the umbilicus and complete paralysis in both legs. Although he was treated with steroid therapy and plasma exchange, his recovery was limited, and severe sequelae remained. Further studies, including large epidemiological studies, are required to understand the association between SARS-CoV-2 vaccines and neurological AEFI.
Keywords: COVID-19; SARS-CoV-2; adverse event following immunization; longitudinally extensive transverse myelitis; transverse myelitis; vaccine.