tetano
Editor, Senior Moderator
Intern Emerg Med
. 2020 Jul 10.
doi: 10.1007/s11739-020-02425-w. Online ahead of print.
Impact of COVID-19 on Liver Function: Results From an Internal Medicine Unit in Northern Italy
Marco Vincenzo Lenti[SUP] 1 [/SUP], Federica Borrelli de Andreis[SUP] 1 [/SUP], Ivan Pellegrino[SUP] 1 [/SUP], Catherine Klersy[SUP] 2 [/SUP], Stefania Merli[SUP] 1 [/SUP], Emanuela Miceli[SUP] 1 [/SUP], Nicola Aronico[SUP] 1 [/SUP], Caterina Mengoli[SUP] 1 [/SUP], Michele Di Stefano[SUP] 1 [/SUP], Sara Cococcia[SUP] 1 [/SUP], Giovanni Santacroce[SUP] 1 [/SUP], Simone Soriano[SUP] 1 [/SUP], Federica Melazzini[SUP] 1 [/SUP], Mariangela Delliponti[SUP] 1 [/SUP], Fausto Baldanti[SUP] 3 [/SUP], Antonio Triarico[SUP] 4 [/SUP], Gino Roberto Corazza[SUP] 1 [/SUP], Massimo Pinzani[SUP] 5 [/SUP], Antonio Di Sabatino[SUP] 6 7 [/SUP], Internal Medicine Covid-19 Team
Collaborators, Affiliations
Abstract
Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25-97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] < 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07-5.11, p = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome.
Keywords: Acute respiratory failure; Coronavirus; Hepatitis; Severe acute respiratory syndrome.
. 2020 Jul 10.
doi: 10.1007/s11739-020-02425-w. Online ahead of print.
Impact of COVID-19 on Liver Function: Results From an Internal Medicine Unit in Northern Italy
Marco Vincenzo Lenti[SUP] 1 [/SUP], Federica Borrelli de Andreis[SUP] 1 [/SUP], Ivan Pellegrino[SUP] 1 [/SUP], Catherine Klersy[SUP] 2 [/SUP], Stefania Merli[SUP] 1 [/SUP], Emanuela Miceli[SUP] 1 [/SUP], Nicola Aronico[SUP] 1 [/SUP], Caterina Mengoli[SUP] 1 [/SUP], Michele Di Stefano[SUP] 1 [/SUP], Sara Cococcia[SUP] 1 [/SUP], Giovanni Santacroce[SUP] 1 [/SUP], Simone Soriano[SUP] 1 [/SUP], Federica Melazzini[SUP] 1 [/SUP], Mariangela Delliponti[SUP] 1 [/SUP], Fausto Baldanti[SUP] 3 [/SUP], Antonio Triarico[SUP] 4 [/SUP], Gino Roberto Corazza[SUP] 1 [/SUP], Massimo Pinzani[SUP] 5 [/SUP], Antonio Di Sabatino[SUP] 6 7 [/SUP], Internal Medicine Covid-19 Team
Collaborators, Affiliations
- PMID: 32651938
- DOI: 10.1007/s11739-020-02425-w
Abstract
Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25-97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] < 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07-5.11, p = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome.
Keywords: Acute respiratory failure; Coronavirus; Hepatitis; Severe acute respiratory syndrome.