tetano
Editor, Senior Moderator
Int J Infect Dis. 2013 Sep 12. pii: S1201-9712(13)00241-5. doi: 10.1016/j.ijid.2013.07.006. [Epub ahead of print]
Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case-control study.
Chiaretti A, Pulitan? S, Conti G, Barone G, Buonsenso D, Manni L, Capozzi D, Ria F, Riccardi R.
Source
Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Largo Gemelli, 1, 00168, Rome, Italy. Electronic address: achiaretti@yahoo.it.
Abstract
OBJECTIVE:
To evaluate the correlation between cytokine and neurotrophin expression and clinical findings, disease severity, and outcome of children with H1N1 influenza infection.
METHODS:
A prospective observational clinical study was performed on 15 children with H1N1 infection, 15 controls with lower respiratory tract infections (LRTI), and 15 non-infected children. Plasma levels of interleukin (IL)-1β, IL-6, and neurotrophic factor (nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), and glial derived neurotrophic factor (GDNF)) were measured using immunoenzymatic assays.
RESULTS:
Significantly higher levels of IL-1β, IL-6, BDNF, and NGF were detected in patients with H1N1 infection compared to LRTI controls, while there was no significant variation in GDNF in the two groups. IL-1β, IL-6, BDNF, and NGF levels were significantly higher in H1N1 patients with more severe clinical manifestations compared to H1N1 patients with mild clinical manifestations. Of note, IL-6 was significantly correlated with the severity of respiratory compromise and fever, while NGF up-regulation was associated with the duration of cough. No correlation was found between interleukin and neurotrophic factor expression and outcome.
CONCLUSIONS:
H1N1 infection induces an early and significant IL-1β, IL-6, BDNF, and NGF up-regulation. The over-expression of these molecular markers is likely to play a neuroimmunomodulatory role in H1N1 infection and may contribute to airway inflammation and bronchial hyper-reactivity in infected children.
Copyright ? 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Brain derived neurotrophic factor, Glial derived neurotrophic factor, H1N1 influenza, Interleukins, Nerve growth factor
PMID:
24094526
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24094526
Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case-control study.
Chiaretti A, Pulitan? S, Conti G, Barone G, Buonsenso D, Manni L, Capozzi D, Ria F, Riccardi R.
Source
Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Largo Gemelli, 1, 00168, Rome, Italy. Electronic address: achiaretti@yahoo.it.
Abstract
OBJECTIVE:
To evaluate the correlation between cytokine and neurotrophin expression and clinical findings, disease severity, and outcome of children with H1N1 influenza infection.
METHODS:
A prospective observational clinical study was performed on 15 children with H1N1 infection, 15 controls with lower respiratory tract infections (LRTI), and 15 non-infected children. Plasma levels of interleukin (IL)-1β, IL-6, and neurotrophic factor (nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), and glial derived neurotrophic factor (GDNF)) were measured using immunoenzymatic assays.
RESULTS:
Significantly higher levels of IL-1β, IL-6, BDNF, and NGF were detected in patients with H1N1 infection compared to LRTI controls, while there was no significant variation in GDNF in the two groups. IL-1β, IL-6, BDNF, and NGF levels were significantly higher in H1N1 patients with more severe clinical manifestations compared to H1N1 patients with mild clinical manifestations. Of note, IL-6 was significantly correlated with the severity of respiratory compromise and fever, while NGF up-regulation was associated with the duration of cough. No correlation was found between interleukin and neurotrophic factor expression and outcome.
CONCLUSIONS:
H1N1 infection induces an early and significant IL-1β, IL-6, BDNF, and NGF up-regulation. The over-expression of these molecular markers is likely to play a neuroimmunomodulatory role in H1N1 infection and may contribute to airway inflammation and bronchial hyper-reactivity in infected children.
Copyright ? 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Brain derived neurotrophic factor, Glial derived neurotrophic factor, H1N1 influenza, Interleukins, Nerve growth factor
PMID:
24094526
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24094526