tetano
Editor, Senior Moderator
Intensive Care Med
. 2023 Aug 24.
doi: 10.1007/s00134-023-07180-y. Online ahead of print. Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre, observational RECOVIDS study
Pierre-Louis Declercq[SUP] 1 [/SUP], Isabelle Fournel[SUP] 2 3 [/SUP], Matthieu Demeyere[SUP] 4 [/SUP], Anissa Berraies[SUP] 5 [/SUP], Eléa Ksiazek[SUP] 2 3 [/SUP], Martine Nyunga[SUP] 6 [/SUP], Cédric Daubin[SUP] 7 [/SUP], Alexandre Ampere[SUP] 8 [/SUP], Bertrand Sauneuf[SUP] 9 [/SUP], Julio Badie[SUP] 10 [/SUP], Agathe Delbove[SUP] 11 [/SUP], Saad Nseir[SUP] 12 13 [/SUP], Elise Artaud-Macari[SUP] 14 [/SUP], Vanessa Bironneau[SUP] 15 16 [/SUP], Michel Ramakers[SUP] 17 [/SUP], Julien Maizel[SUP] 18 [/SUP], Arnaud-Felix Miailhe[SUP] 19 [/SUP], Béatrice Lacombe[SUP] 20 [/SUP], Nicolas Delberghe[SUP] 21 [/SUP], Walid Oulehri[SUP] 22 [/SUP], Hugues Georges[SUP] 23 [/SUP], Xavier Tchenio[SUP] 24 [/SUP], Caroline Clarot[SUP] 25 [/SUP], Elise Redureau[SUP] 26 [/SUP], Gaël Bourdin[SUP] 27 [/SUP], Laura Federici[SUP] 28 [/SUP], Mélanie Adda[SUP] 29 [/SUP], David Schnell[SUP] 30 [/SUP], Mehdi Bousta[SUP] 31 [/SUP], Charlotte Salmon-Gandonnière[SUP] 32 [/SUP], Thierry Vanderlinden[SUP] 33 [/SUP], Gaëtan Plantefeve[SUP] 34 [/SUP], David Delacour[SUP] 35 [/SUP], Cyrille Delpierre[SUP] 36 [/SUP], Gurvan Le Bouar[SUP] 37 [/SUP], Nicholas Sedillot[SUP] 24 [/SUP], Gaëtan Beduneau[SUP] 38 [/SUP], Antoine Rivière[SUP] 39 [/SUP], Nicolas Meunier-Beillard[SUP] 2 3 [/SUP], Stéphanie Gélinotte[SUP] 1 [/SUP], Jean-Philippe Rigaud[SUP] 1 40 [/SUP], Marie Labruyère[SUP] 41 42 43 [/SUP], Marjolaine Georges[SUP] 44 [/SUP], Christine Binquet[SUP] 2 3 [/SUP], Jean-Pierre Quenot[SUP] 45 46 47 [/SUP]; RECOVIDS trial investigators, the CRICS-TRIGGERSEP, BOREAL research networks
Collaborators, Affiliations
Purpose: Survivors after acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) are at high risk of developing respiratory sequelae and functional impairment. The healthcare crisis caused by the pandemic hit socially disadvantaged populations. We aimed to evaluate the influence of socio-economic status on respiratory sequelae after COVID-19 ARDS.
Methods: We carried out a prospective multicenter study in 30 French intensive care units (ICUs), where ARDS survivors were pre-enrolled if they fulfilled the Berlin ARDS criteria. For patients receiving high flow oxygen therapy, a flow ≥ 50 l/min and an FiO[SUB]2[/SUB] ≥ 50% were required for enrollment. Socio-economic deprivation was defined by an EPICES (Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examens de Santé - Evaluation of Deprivation and Inequalities in Health Examination Centres) score ≥ 30.17 and patients were included if they performed the 6-month evaluation. The primary outcome was respiratory sequelae 6 months after ICU discharge, defined by at least one of the following criteria: forced vital capacity < 80% of theoretical value, diffusing capacity of the lung for carbon monoxide < 80% of theoretical value, oxygen desaturation during a 6-min walk test and fibrotic-like findings on chest computed tomography.
Results: Among 401 analyzable patients, 160 (40%) were socio-economically deprived and 241 (60%) non-deprived; 319 (80%) patients had respiratory sequelae 6 months after ICU discharge (81% vs 78%, deprived vs non-deprived, respectively). No significant effect of socio-economic status was identified on lung sequelae (odds ratio (OR), 1.19 [95% confidence interval (CI), 0.72-1.97]), even after adjustment for age, sex, most invasive respiratory support, obesity, most severe P/F ratio (adjusted OR, 1.02 [95% CI 0.57-1.83]).
Conclusions: In COVID-19 ARDS survivors, socio-economic status had no significant influence on respiratory sequelae 6 months after ICU discharge.
Keywords: ARDS; COVID-19; Deprivation; Respiratory sequelae; Socio-economic.
. 2023 Aug 24.
doi: 10.1007/s00134-023-07180-y. Online ahead of print. Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre, observational RECOVIDS study
Pierre-Louis Declercq[SUP] 1 [/SUP], Isabelle Fournel[SUP] 2 3 [/SUP], Matthieu Demeyere[SUP] 4 [/SUP], Anissa Berraies[SUP] 5 [/SUP], Eléa Ksiazek[SUP] 2 3 [/SUP], Martine Nyunga[SUP] 6 [/SUP], Cédric Daubin[SUP] 7 [/SUP], Alexandre Ampere[SUP] 8 [/SUP], Bertrand Sauneuf[SUP] 9 [/SUP], Julio Badie[SUP] 10 [/SUP], Agathe Delbove[SUP] 11 [/SUP], Saad Nseir[SUP] 12 13 [/SUP], Elise Artaud-Macari[SUP] 14 [/SUP], Vanessa Bironneau[SUP] 15 16 [/SUP], Michel Ramakers[SUP] 17 [/SUP], Julien Maizel[SUP] 18 [/SUP], Arnaud-Felix Miailhe[SUP] 19 [/SUP], Béatrice Lacombe[SUP] 20 [/SUP], Nicolas Delberghe[SUP] 21 [/SUP], Walid Oulehri[SUP] 22 [/SUP], Hugues Georges[SUP] 23 [/SUP], Xavier Tchenio[SUP] 24 [/SUP], Caroline Clarot[SUP] 25 [/SUP], Elise Redureau[SUP] 26 [/SUP], Gaël Bourdin[SUP] 27 [/SUP], Laura Federici[SUP] 28 [/SUP], Mélanie Adda[SUP] 29 [/SUP], David Schnell[SUP] 30 [/SUP], Mehdi Bousta[SUP] 31 [/SUP], Charlotte Salmon-Gandonnière[SUP] 32 [/SUP], Thierry Vanderlinden[SUP] 33 [/SUP], Gaëtan Plantefeve[SUP] 34 [/SUP], David Delacour[SUP] 35 [/SUP], Cyrille Delpierre[SUP] 36 [/SUP], Gurvan Le Bouar[SUP] 37 [/SUP], Nicholas Sedillot[SUP] 24 [/SUP], Gaëtan Beduneau[SUP] 38 [/SUP], Antoine Rivière[SUP] 39 [/SUP], Nicolas Meunier-Beillard[SUP] 2 3 [/SUP], Stéphanie Gélinotte[SUP] 1 [/SUP], Jean-Philippe Rigaud[SUP] 1 40 [/SUP], Marie Labruyère[SUP] 41 42 43 [/SUP], Marjolaine Georges[SUP] 44 [/SUP], Christine Binquet[SUP] 2 3 [/SUP], Jean-Pierre Quenot[SUP] 45 46 47 [/SUP]; RECOVIDS trial investigators, the CRICS-TRIGGERSEP, BOREAL research networks
Collaborators, Affiliations
- PMID: 37620561
- DOI: 10.1007/s00134-023-07180-y
Purpose: Survivors after acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) are at high risk of developing respiratory sequelae and functional impairment. The healthcare crisis caused by the pandemic hit socially disadvantaged populations. We aimed to evaluate the influence of socio-economic status on respiratory sequelae after COVID-19 ARDS.
Methods: We carried out a prospective multicenter study in 30 French intensive care units (ICUs), where ARDS survivors were pre-enrolled if they fulfilled the Berlin ARDS criteria. For patients receiving high flow oxygen therapy, a flow ≥ 50 l/min and an FiO[SUB]2[/SUB] ≥ 50% were required for enrollment. Socio-economic deprivation was defined by an EPICES (Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examens de Santé - Evaluation of Deprivation and Inequalities in Health Examination Centres) score ≥ 30.17 and patients were included if they performed the 6-month evaluation. The primary outcome was respiratory sequelae 6 months after ICU discharge, defined by at least one of the following criteria: forced vital capacity < 80% of theoretical value, diffusing capacity of the lung for carbon monoxide < 80% of theoretical value, oxygen desaturation during a 6-min walk test and fibrotic-like findings on chest computed tomography.
Results: Among 401 analyzable patients, 160 (40%) were socio-economically deprived and 241 (60%) non-deprived; 319 (80%) patients had respiratory sequelae 6 months after ICU discharge (81% vs 78%, deprived vs non-deprived, respectively). No significant effect of socio-economic status was identified on lung sequelae (odds ratio (OR), 1.19 [95% confidence interval (CI), 0.72-1.97]), even after adjustment for age, sex, most invasive respiratory support, obesity, most severe P/F ratio (adjusted OR, 1.02 [95% CI 0.57-1.83]).
Conclusions: In COVID-19 ARDS survivors, socio-economic status had no significant influence on respiratory sequelae 6 months after ICU discharge.
Keywords: ARDS; COVID-19; Deprivation; Respiratory sequelae; Socio-economic.