tetano
Editor, Senior Moderator
Int J Surg Pathol
. 2023 Jun 4;10668969231177877.
doi: 10.1177/10668969231177877. Online ahead of print. Clinicopathological Characteristics of Autoimmune-Like Hepatitis Induced by COVID-19 mRNA Vaccine (Pfizer-BioNTech, BNT162b2): A Case Report and Literature Review
Ji Hyoun Kim[SUP] 1 2 [/SUP], Hee Bok Chae[SUP] 2 3 [/SUP], Sumin Woo[SUP] 2 [/SUP], Myung Seop Song[SUP] 2 [/SUP], Hyo-Jong Kim[SUP] 2 4 [/SUP], Chang Gok Woo[SUP] 2 5 [/SUP]
Affiliations
Widespread use of vaccinations worldwide in the coronavirus disease (COVID-19) pandemic has resulted in various side effects. Here, we presented a 27-year-old man with autoimmune-like hepatitis after the first dose of the BNT162b2 (mRNA) COVID-19 vaccine and reviewed previous reports. He presented with sweating, febrile sensations, and general weakness. He did not have any medical histories. Although he was treated with biphenyl dimethyl dicarboxylate and ursodeoxycholic acid, the elevated liver enzyme levels persisted for 2 months. Liver biopsy demonstrated portal inflammation with rosette formation, interface hepatitis, and infiltration of lymphocytes, histiocytes, plasma cells, and eosinophils. Especially, centrilobular edema and necrosis were found. The symptoms and liver enzymes improved with prednisolone treatment. If persistently elevated liver enzymes are found after COVID-19 mRNA vaccination, the possibility of autoimmune-like hepatitis induced by the vaccine should be considered and a careful pathologic evaluation is required.
Keywords: autoimmune hepatitis; coronavirus; drug-induced liver injury; mRNA vaccine; vaccination.
. 2023 Jun 4;10668969231177877.
doi: 10.1177/10668969231177877. Online ahead of print. Clinicopathological Characteristics of Autoimmune-Like Hepatitis Induced by COVID-19 mRNA Vaccine (Pfizer-BioNTech, BNT162b2): A Case Report and Literature Review
Ji Hyoun Kim[SUP] 1 2 [/SUP], Hee Bok Chae[SUP] 2 3 [/SUP], Sumin Woo[SUP] 2 [/SUP], Myung Seop Song[SUP] 2 [/SUP], Hyo-Jong Kim[SUP] 2 4 [/SUP], Chang Gok Woo[SUP] 2 5 [/SUP]
Affiliations
- PMID: 37272061
- DOI: 10.1177/10668969231177877
Widespread use of vaccinations worldwide in the coronavirus disease (COVID-19) pandemic has resulted in various side effects. Here, we presented a 27-year-old man with autoimmune-like hepatitis after the first dose of the BNT162b2 (mRNA) COVID-19 vaccine and reviewed previous reports. He presented with sweating, febrile sensations, and general weakness. He did not have any medical histories. Although he was treated with biphenyl dimethyl dicarboxylate and ursodeoxycholic acid, the elevated liver enzyme levels persisted for 2 months. Liver biopsy demonstrated portal inflammation with rosette formation, interface hepatitis, and infiltration of lymphocytes, histiocytes, plasma cells, and eosinophils. Especially, centrilobular edema and necrosis were found. The symptoms and liver enzymes improved with prednisolone treatment. If persistently elevated liver enzymes are found after COVID-19 mRNA vaccination, the possibility of autoimmune-like hepatitis induced by the vaccine should be considered and a careful pathologic evaluation is required.
Keywords: autoimmune hepatitis; coronavirus; drug-induced liver injury; mRNA vaccine; vaccination.