tetano
Editor, Senior Moderator
Int J Neurosci
. 2020 Dec 5;1-7.
doi: 10.1080/00207454.2020.1860036. Online ahead of print.
Covid-19 Infection Induced Neuromyelitis Optica - A Case Report
Melike Batum[SUP] 1 [/SUP], Aysin Kisabay Ak[SUP] 1 [/SUP], Hatice Mavioğlu[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Acute respiratory syndrome coronavirus-2 (Covid 19) can infect the respiratory system, as well as the central, peripheral nervous system and muscles, leading to neurological symptoms and signs. The most common neurological symptoms are dizziness, headache, impaired consciousness, ataxia, hypogosis, hyposmia, neuralgia and myalgia. The most common neurological diseases are acute cerebrovascular disease, epilepsy, acute hemorrhagic necrotizing encephalopathy, miyelitis and Gullian Barre Syndrome. Methods: In this case report, a patient infected with Covid 19 and diagnosed as neuromyelitis optica (NMO) with anamnesis, clinical and radiological findings is presented. Results: A 50 years old woman presented with weakness of both legs, urine retention, high fever, and cough. Spinal magnetic resonance imaging revealed expensive long-segment and centrally located demyelinating lesion extending from the cervical cord (at the level of C3) to the conus. Thoracic computerized tomography revealed consolidation areas located on the lower segments of bilateral lungs and ground-glass density, air bronchograms, and peribronchial thickening surrounding these areas. Aquaporin-4 immune globulin-G was found to be positive. Conclusion: It was considered appropriate to present this case because of being the first case of parainfectious NMO considered to be induced by SARS-CoV-2. HIGHLIGHTS COVID-19 has neuro-invasion potential independently of the critical disease process Demyelinating lesions such as neuromyelitis optica may develop in the course of disease Parainfectious NMO induced by SARS-CoV-2 may occur as a result of extended immune response.
Keywords: Covid-19; demyelinating lesion; neuromyelitis optica; parainfectious myelitis; spinal cord.
. 2020 Dec 5;1-7.
doi: 10.1080/00207454.2020.1860036. Online ahead of print.
Covid-19 Infection Induced Neuromyelitis Optica - A Case Report
Melike Batum[SUP] 1 [/SUP], Aysin Kisabay Ak[SUP] 1 [/SUP], Hatice Mavioğlu[SUP] 1 [/SUP]
Affiliations
- PMID: 33280477
- DOI: 10.1080/00207454.2020.1860036
Abstract
Introduction: Acute respiratory syndrome coronavirus-2 (Covid 19) can infect the respiratory system, as well as the central, peripheral nervous system and muscles, leading to neurological symptoms and signs. The most common neurological symptoms are dizziness, headache, impaired consciousness, ataxia, hypogosis, hyposmia, neuralgia and myalgia. The most common neurological diseases are acute cerebrovascular disease, epilepsy, acute hemorrhagic necrotizing encephalopathy, miyelitis and Gullian Barre Syndrome. Methods: In this case report, a patient infected with Covid 19 and diagnosed as neuromyelitis optica (NMO) with anamnesis, clinical and radiological findings is presented. Results: A 50 years old woman presented with weakness of both legs, urine retention, high fever, and cough. Spinal magnetic resonance imaging revealed expensive long-segment and centrally located demyelinating lesion extending from the cervical cord (at the level of C3) to the conus. Thoracic computerized tomography revealed consolidation areas located on the lower segments of bilateral lungs and ground-glass density, air bronchograms, and peribronchial thickening surrounding these areas. Aquaporin-4 immune globulin-G was found to be positive. Conclusion: It was considered appropriate to present this case because of being the first case of parainfectious NMO considered to be induced by SARS-CoV-2. HIGHLIGHTS COVID-19 has neuro-invasion potential independently of the critical disease process Demyelinating lesions such as neuromyelitis optica may develop in the course of disease Parainfectious NMO induced by SARS-CoV-2 may occur as a result of extended immune response.
Keywords: Covid-19; demyelinating lesion; neuromyelitis optica; parainfectious myelitis; spinal cord.