tetano
Editor, Senior Moderator
Int J Mol Sci
. 2022 Dec 1;23(23):15126.
doi: 10.3390/ijms232315126.
A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19
Jeeshan Singh[SUP] 1 2 [/SUP], Irmgard Herrmann[SUP] 1 2 [/SUP], Aparna Mahajan[SUP] 1 2 [/SUP], Christine Schauer[SUP] 1 2 [/SUP], Xiaomei Shan[SUP] 1 2 [/SUP], Arndt Hartmann[SUP] 3 [/SUP], Ralf J Rieker[SUP] 3 [/SUP], Katja Evert[SUP] 4 [/SUP], Christina Falkeis[SUP] 5 [/SUP], Elisabeth Naschberger[SUP] 6 [/SUP], Saskia von Stillfried[SUP] 7 [/SUP], Peter Boor[SUP] 7 [/SUP], Luis E Muñoz[SUP] 1 2 [/SUP], Georg Schett[SUP] 1 2 [/SUP], Martin Herrmann[SUP] 1 2 [/SUP], Jasmin Knopf[SUP] 1 2 [/SUP]
Affiliations
Abstract
Vascular occlusions in patients with coronavirus diseases 2019 (COVID-19) have been frequently reported in severe outcomes mainly due to a dysregulation of neutrophils mediating neutrophil extracellular trap (NET) formation. Lung specimens from patients with COVID-19 have previously shown a dynamic morphology, categorized into three types of pleomorphic occurrence based on histological findings in this study. These vascular occlusions in lung specimens were also detected using native endogenous fluorescence or NEF in a label-free method. The three types of vascular occlusions exhibit morphology of DNA rich neutrophil elastase (NE) poor (type I), NE rich DNA poor (type II), and DNA and NE rich (type III) cohort of eleven patients with six males and five females. Age and gender have been presented in this study as influencing variables linking the occurrence of several occlusions with pleomorphic contents within a patient specimen and amongst them. This study reports the categorization of pleomorphic occlusions in patients with COVID-19 and the detection of these occlusions in a label-free method utilizing NEF.
Keywords: COVID-19; SARS-CoV-2; age; gender; immunothrombosis; native endogenous fluorescence; occlusions; pleomorphism.
. 2022 Dec 1;23(23):15126.
doi: 10.3390/ijms232315126.
A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19
Jeeshan Singh[SUP] 1 2 [/SUP], Irmgard Herrmann[SUP] 1 2 [/SUP], Aparna Mahajan[SUP] 1 2 [/SUP], Christine Schauer[SUP] 1 2 [/SUP], Xiaomei Shan[SUP] 1 2 [/SUP], Arndt Hartmann[SUP] 3 [/SUP], Ralf J Rieker[SUP] 3 [/SUP], Katja Evert[SUP] 4 [/SUP], Christina Falkeis[SUP] 5 [/SUP], Elisabeth Naschberger[SUP] 6 [/SUP], Saskia von Stillfried[SUP] 7 [/SUP], Peter Boor[SUP] 7 [/SUP], Luis E Muñoz[SUP] 1 2 [/SUP], Georg Schett[SUP] 1 2 [/SUP], Martin Herrmann[SUP] 1 2 [/SUP], Jasmin Knopf[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36499449
- DOI: 10.3390/ijms232315126
Abstract
Vascular occlusions in patients with coronavirus diseases 2019 (COVID-19) have been frequently reported in severe outcomes mainly due to a dysregulation of neutrophils mediating neutrophil extracellular trap (NET) formation. Lung specimens from patients with COVID-19 have previously shown a dynamic morphology, categorized into three types of pleomorphic occurrence based on histological findings in this study. These vascular occlusions in lung specimens were also detected using native endogenous fluorescence or NEF in a label-free method. The three types of vascular occlusions exhibit morphology of DNA rich neutrophil elastase (NE) poor (type I), NE rich DNA poor (type II), and DNA and NE rich (type III) cohort of eleven patients with six males and five females. Age and gender have been presented in this study as influencing variables linking the occurrence of several occlusions with pleomorphic contents within a patient specimen and amongst them. This study reports the categorization of pleomorphic occlusions in patients with COVID-19 and the detection of these occlusions in a label-free method utilizing NEF.
Keywords: COVID-19; SARS-CoV-2; age; gender; immunothrombosis; native endogenous fluorescence; occlusions; pleomorphism.