tetano
Editor, Senior Moderator
Int J Med Sci
. 2021 Jan 29;18(6):1474-1483.
doi: 10.7150/ijms.53641. eCollection 2021.
Cardiac Troponin I association with critical illness and death risk in 726 seriously ill COVID-19 patients: A retrospective cohort study
Huilong Chen[SUP] 1 [/SUP], Xinjie Li[SUP] 2 [/SUP], Tuohutaerbieke Marmar[SUP] 2 [/SUP], Qiang Xu[SUP] 2 [/SUP], Jing Tu[SUP] 2 [/SUP], Tong Li[SUP] 2 [/SUP], Jun Han[SUP] 3 [/SUP], Dong Xu[SUP] 1 [/SUP], Tao Shen[SUP] 2 [/SUP]
Affiliations
Abstract
Background: For coronavirus disease 2019 (COVID-19), early identification of patients with serious symptoms at risk of critical illness and death is important for personalized treatment and balancing medical resources. Methods: Demographics, clinical characteristics, and laboratory tests data from 726 patients with serious COVID-19 at Tongji Hospital (Wuhan, China) were analyzed. Patients were classified into critical group (n = 174) and severe group (n= 552), the critical group was sub-divided into survivors (n = 47) and non-survivors (n = 127). Results: Multivariable analyses revealed the risk factors associated with critical illness in serious patients were: Advanced age, high respiratory rate (RR), high lactate dehydrogenase (LDH) level, high hypersensitive cardiac troponin I (hs-cTnI) level, and thrombocytopenia on admission. High hs-cTnI level was the independent risk factor of mortality among critically ill patients in the unadjusted and adjusted models. ROC curves demonstrated that hs-cTnI and LDH were predictive factors for critical illness in patients with serious COVID-19 whereas procalcitonin and D-Dimer with hs-cTnI and LDH were predictive parameters in mortality risk. Conclusions: Advanced age, high RR, LDH, hs-cTnI, and thrombocytopenia, constitute risk factors for critical illness among patients with serious COVID-19, and the hs-cTnI level helps predict fatal outcomes in critically ill patients.
Keywords: Coronavirus disease 2019 (COVID-19); hypersensitive cardiac troponin I (hs-cTnI); lactate dehydrogenase (LDH); prognosis; severe acute respiratory syndrome coronavirus (SARS-CoV-2).
. 2021 Jan 29;18(6):1474-1483.
doi: 10.7150/ijms.53641. eCollection 2021.
Cardiac Troponin I association with critical illness and death risk in 726 seriously ill COVID-19 patients: A retrospective cohort study
Huilong Chen[SUP] 1 [/SUP], Xinjie Li[SUP] 2 [/SUP], Tuohutaerbieke Marmar[SUP] 2 [/SUP], Qiang Xu[SUP] 2 [/SUP], Jing Tu[SUP] 2 [/SUP], Tong Li[SUP] 2 [/SUP], Jun Han[SUP] 3 [/SUP], Dong Xu[SUP] 1 [/SUP], Tao Shen[SUP] 2 [/SUP]
Affiliations
- PMID: 33628105
- PMCID: PMC7893554
- DOI: 10.7150/ijms.53641
Abstract
Background: For coronavirus disease 2019 (COVID-19), early identification of patients with serious symptoms at risk of critical illness and death is important for personalized treatment and balancing medical resources. Methods: Demographics, clinical characteristics, and laboratory tests data from 726 patients with serious COVID-19 at Tongji Hospital (Wuhan, China) were analyzed. Patients were classified into critical group (n = 174) and severe group (n= 552), the critical group was sub-divided into survivors (n = 47) and non-survivors (n = 127). Results: Multivariable analyses revealed the risk factors associated with critical illness in serious patients were: Advanced age, high respiratory rate (RR), high lactate dehydrogenase (LDH) level, high hypersensitive cardiac troponin I (hs-cTnI) level, and thrombocytopenia on admission. High hs-cTnI level was the independent risk factor of mortality among critically ill patients in the unadjusted and adjusted models. ROC curves demonstrated that hs-cTnI and LDH were predictive factors for critical illness in patients with serious COVID-19 whereas procalcitonin and D-Dimer with hs-cTnI and LDH were predictive parameters in mortality risk. Conclusions: Advanced age, high RR, LDH, hs-cTnI, and thrombocytopenia, constitute risk factors for critical illness among patients with serious COVID-19, and the hs-cTnI level helps predict fatal outcomes in critically ill patients.
Keywords: Coronavirus disease 2019 (COVID-19); hypersensitive cardiac troponin I (hs-cTnI); lactate dehydrogenase (LDH); prognosis; severe acute respiratory syndrome coronavirus (SARS-CoV-2).