tetano
Editor, Senior Moderator
Int J Med Sci
. 2020 Jul 25;17(13):2052-2062.
doi: 10.7150/ijms.47935. eCollection 2020.
Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China
Xia Xu[SUP] 1 [/SUP], Mu-Qing Yu[SUP] 2 [/SUP], Qian Shen[SUP] 3 [/SUP], Lian-Zhong Wang[SUP] 4 [/SUP], Rong-Di Yan[SUP] 4 [/SUP], Meng-Yu Zhang[SUP] 5 [/SUP], Jian-Yu Liu[SUP] 5 [/SUP], Yi-Qing Qu[SUP] 6 [/SUP]
Affiliations
Abstract
Background and aim: The outbreak of coronavirus disease 2019 (COVID-19) is quickly turning into a pandemic. We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity. Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. Results: 88 hospitalization patients confirmed COVID-19 were enrolled in this study. The average age of the patients was 57.11 years (SD, ?15.39). Of these 88 patients, the median body mass index (BMI) was 24.03 (IQR, 21.64-26.61; range 15.05-32.39), the median duration from disease onset to hospital admission were 11 days (IQR, 6.50-14.50). 46.59% patients had one or more comorbidities, with hypertension being the most common (26.14%), followed by diabetes mellitus (12.50%) and coronary atherosclerotic heart disease (CAD) (7.95%). Common symptoms at onset of disease were fever (71.59%), cough (59.09%), dyspnea (38.64%) and fatigue (29.55%). 88 patients were divided into moderate (47 [53.41%]), severe (32 [36.36%]) and critically ill (9 [10.23%]) groups. Compared with severe and moderate patients, lymphocytopenia occurred in 85.71% critically ill patients, and serum IL-2R, IL-6, IL-8, TNF-α, LDH, and cTnI were also increased in 71.42%, 83.33%, 57.14%, 71.43%, 100% and 42.86% in critically ill patients. Through our analysis, the age, comorbidities, lymphocyte count, eosinophil count, ferritin, CRP, LDH, PT and inflammatory cytokines were statistically significant along with the disease severity. Conclusion: We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage. Our research could assist the clinicians recognize severe and critically ill patients timely and focus on the expectant treatment for each patient.
Keywords: COVID-19; clinical characteristics; disease severity; inflammatory cytokines; outbreak phage.
. 2020 Jul 25;17(13):2052-2062.
doi: 10.7150/ijms.47935. eCollection 2020.
Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China
Xia Xu[SUP] 1 [/SUP], Mu-Qing Yu[SUP] 2 [/SUP], Qian Shen[SUP] 3 [/SUP], Lian-Zhong Wang[SUP] 4 [/SUP], Rong-Di Yan[SUP] 4 [/SUP], Meng-Yu Zhang[SUP] 5 [/SUP], Jian-Yu Liu[SUP] 5 [/SUP], Yi-Qing Qu[SUP] 6 [/SUP]
Affiliations
- PMID: 32788884
- PMCID: PMC7415392
- DOI: 10.7150/ijms.47935
Abstract
Background and aim: The outbreak of coronavirus disease 2019 (COVID-19) is quickly turning into a pandemic. We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity. Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. Results: 88 hospitalization patients confirmed COVID-19 were enrolled in this study. The average age of the patients was 57.11 years (SD, ?15.39). Of these 88 patients, the median body mass index (BMI) was 24.03 (IQR, 21.64-26.61; range 15.05-32.39), the median duration from disease onset to hospital admission were 11 days (IQR, 6.50-14.50). 46.59% patients had one or more comorbidities, with hypertension being the most common (26.14%), followed by diabetes mellitus (12.50%) and coronary atherosclerotic heart disease (CAD) (7.95%). Common symptoms at onset of disease were fever (71.59%), cough (59.09%), dyspnea (38.64%) and fatigue (29.55%). 88 patients were divided into moderate (47 [53.41%]), severe (32 [36.36%]) and critically ill (9 [10.23%]) groups. Compared with severe and moderate patients, lymphocytopenia occurred in 85.71% critically ill patients, and serum IL-2R, IL-6, IL-8, TNF-α, LDH, and cTnI were also increased in 71.42%, 83.33%, 57.14%, 71.43%, 100% and 42.86% in critically ill patients. Through our analysis, the age, comorbidities, lymphocyte count, eosinophil count, ferritin, CRP, LDH, PT and inflammatory cytokines were statistically significant along with the disease severity. Conclusion: We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage. Our research could assist the clinicians recognize severe and critically ill patients timely and focus on the expectant treatment for each patient.
Keywords: COVID-19; clinical characteristics; disease severity; inflammatory cytokines; outbreak phage.