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Int J Infect Dis . The global region-specific epidemiologic characteristics of influenza: WHO FluNet data from 1996 to 2021

tetano

Editor, Senior Moderator
Int J Infect Dis


. 2023 Feb 9;S1201-9712(23)00052-8.
doi: 10.1016/j.ijid.2023.02.002. Online ahead of print.
The global region-specific epidemiologic characteristics of influenza: WHO FluNet data from 1996 to 2021


Can Chen[SUP] 1 [/SUP], Daixi Jiang[SUP] 1 [/SUP], Danying Yan[SUP] 1 [/SUP], Lucheng Pi[SUP] 2 [/SUP], Xiaobao Zhang[SUP] 1 [/SUP], Yuxia Du[SUP] 1 [/SUP], Xiaoxiao Liu[SUP] 1 [/SUP], Mengya Yang[SUP] 1 [/SUP], Yuqing Zhou[SUP] 1 [/SUP], Cheng Ding[SUP] 1 [/SUP], Lei Lan[SUP] 1 [/SUP], Shigui Yang[SUP] 3 [/SUP]



Affiliations
Free article

Abstract

Background: This study aimed to investigate region-specific epidemiologic characteristics of influenza and influenza transmission zones (ITZs).
Methods: Weekly influenza surveillance data of 156 countries from 1996 to 2021 were obtained using FluNet. Join-point regression was used to describe global influenza virus trends, and clustering analyses were used to classify the ITZs.
Results: The global median average positive rate for total influenza virus was 16.19% (interquartile range [IQR]:11.62%-25.70%). Overall, three major subtypes (influenza H1, H3, and B viruses) showed alternating epidemics. Notably, the proportion of influenza B viruses increased significantly from July 2020 to June 2021, reaching 62.66%. The primary peaks of influenza virus circulation in the north were earlier than those in the south. Global influenza virus circulation was significantly characterised by seven ITZs, including "Northern-America" (primary peak: week 10), "Eastern & Southern-Asia" (primary peak: week 10), "Europe" (primary peak: week 11), "Asia-Europe" (primary peak: week 12), "Southern-America" (primary peak: week 30), "Oceania-Melanesia-Polynesia" (primary peak: week 39), and "Africa" (primary peak: week 46).
Conclusions: Global influenza virus circulation was significantly characterised by seven ITZs that could be applied to influenza surveillance and warning.

Keywords: Epidemiologic characteristics; Influenza transmission zones; Influenza virus; Trends.
 
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