tetano
Editor, Senior Moderator
Int J Infect Dis
. 2022 Oct 19;S1201-9712(22)00558-6.
doi: 10.1016/j.ijid.2022.10.019. Online ahead of print.
SARS-CoV-2 vertical transmission in a twin-pregnant woman: a case report
Rosa Sessa[SUP] 1 [/SUP], Luisa Masciullo[SUP] 2 [/SUP], Simone Filardo[SUP] 3 [/SUP], Marisa Di Pietro[SUP] 1 [/SUP], Gabriella Brandolino[SUP] 2 [/SUP], Roberto Brunelli[SUP] 2 [/SUP], Paola Galoppi[SUP] 2 [/SUP], Gianluca Terrin[SUP] 2 [/SUP], Maria Federica Viscardi[SUP] 2 [/SUP], Emanuela Anastasi[SUP] 4 [/SUP], Maria Grazia Porpora[SUP] 2 [/SUP]
Affiliations
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) has affected millions of people around the world in the last years. Among susceptible patients, pregnant women seem to be prone to have serious complications. The possibility of SARS-CoV-2 vertical transmission represents one of the most debated topics in the literature, providing inconclusive results. We present a case of a confirmed vertical transmission in a monochorial diamniotic twin pregnancy complicated by a selective intrauterine growth restriction (sIUGR) and gestational diabetes. The analysis of different biological specimens identifies the presence of SARS-CoV2 genome in the umbilical cord blood of both twins and the placental histologic examination confirmed indirect signs of viral infection, supporting the hypothesis that a transplacental infection can occur. Despite the devastating impact that SARS-CoV2 has worldwide, neonatal infections have been infrequently reported but they can occur under certain biologic conditions. A deep knowledge of the biological mechanisms underlying the risk of SARS-CoV-2 vertical transmission might be useful to understand the pathophysiological bases and the possible long-term implication of a mother-to-child vertical transmission.
Keywords: Obstetric outcomes; Placenta; Pregnancy; SARS-CoV-2 infection; Vertical transmission.
. 2022 Oct 19;S1201-9712(22)00558-6.
doi: 10.1016/j.ijid.2022.10.019. Online ahead of print.
SARS-CoV-2 vertical transmission in a twin-pregnant woman: a case report
Rosa Sessa[SUP] 1 [/SUP], Luisa Masciullo[SUP] 2 [/SUP], Simone Filardo[SUP] 3 [/SUP], Marisa Di Pietro[SUP] 1 [/SUP], Gabriella Brandolino[SUP] 2 [/SUP], Roberto Brunelli[SUP] 2 [/SUP], Paola Galoppi[SUP] 2 [/SUP], Gianluca Terrin[SUP] 2 [/SUP], Maria Federica Viscardi[SUP] 2 [/SUP], Emanuela Anastasi[SUP] 4 [/SUP], Maria Grazia Porpora[SUP] 2 [/SUP]
Affiliations
- PMID: 36272699
- DOI: 10.1016/j.ijid.2022.10.019
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) has affected millions of people around the world in the last years. Among susceptible patients, pregnant women seem to be prone to have serious complications. The possibility of SARS-CoV-2 vertical transmission represents one of the most debated topics in the literature, providing inconclusive results. We present a case of a confirmed vertical transmission in a monochorial diamniotic twin pregnancy complicated by a selective intrauterine growth restriction (sIUGR) and gestational diabetes. The analysis of different biological specimens identifies the presence of SARS-CoV2 genome in the umbilical cord blood of both twins and the placental histologic examination confirmed indirect signs of viral infection, supporting the hypothesis that a transplacental infection can occur. Despite the devastating impact that SARS-CoV2 has worldwide, neonatal infections have been infrequently reported but they can occur under certain biologic conditions. A deep knowledge of the biological mechanisms underlying the risk of SARS-CoV-2 vertical transmission might be useful to understand the pathophysiological bases and the possible long-term implication of a mother-to-child vertical transmission.
Keywords: Obstetric outcomes; Placenta; Pregnancy; SARS-CoV-2 infection; Vertical transmission.