tetano
Editor, Senior Moderator
Int J Infect Dis
. 2025 Dec 17:108312.
doi: 10.1016/j.ijid.2025.108312. Online ahead of print. Increased 30-day Mortality Risk in Coronavirus Disease 2019 Compared to Seasonal Influenza
Won Suk Choi[SUP] 1 [/SUP], Kyoung-Hoon Kim[SUP] 2 [/SUP], Dong-Sook Kim[SUP] 3 [/SUP], Seo-Hyun Lee[SUP] 4 [/SUP], Ji-Eun An[SUP] 5 [/SUP], Su-Yeon Yu[SUP] 6 [/SUP]
Affiliations
Objectives: To compare 30-day all-cause mortality between patients with coronavirus disease 2019 (COVID-19) and those with seasonal influenza in South Korea.
Design: This nationwide, population-based cohort study utilized the National Health Insurance claim database, including individuals newly diagnosed with COVID-19 or influenza between July 2022 and December 2023. The primary outcome was 30-day all-cause mortality. Logistic regression analysis was conducted to compare mortality risks, adjusting for demographic and clinical covariates.
Results: A total of 12,802,169 patients with COVID-19 and 2,888,777 patients with influenza were analyzed. COVID-19 was associated with significantly higher 30-day all-cause mortality compared with influenza (adjusted odds ratio [aOR], 1.76; 95% CI, 1.60-1.94). This elevated risk remained consistent across most subgroups defined by age, sex, healthcare utilization, and comorbidities. Particularly higher risks were observed among adults aged 18-64 years (aOR, 2.93), hospitalized patients (aOR, 2.55), and those with myocardial infarction (aOR, 2.24).
Conclusions: COVID-19 is associated with markedly higher short-term mortality than influenza across diverse clinical and demographic subgroups. These findings underscore the ongoing need for vigilant prevention efforts, and vaccination. This study represents the first large-scale nationwide analysis, and the first in Asia, conducted in the post-COVID-19 era.
Keywords: 30-day mortality; COVID-19; Health Insurance Claims Data; influenza.
. 2025 Dec 17:108312.
doi: 10.1016/j.ijid.2025.108312. Online ahead of print. Increased 30-day Mortality Risk in Coronavirus Disease 2019 Compared to Seasonal Influenza
Won Suk Choi[SUP] 1 [/SUP], Kyoung-Hoon Kim[SUP] 2 [/SUP], Dong-Sook Kim[SUP] 3 [/SUP], Seo-Hyun Lee[SUP] 4 [/SUP], Ji-Eun An[SUP] 5 [/SUP], Su-Yeon Yu[SUP] 6 [/SUP]
Affiliations
- PMID: 41418925
- DOI: 10.1016/j.ijid.2025.108312
Objectives: To compare 30-day all-cause mortality between patients with coronavirus disease 2019 (COVID-19) and those with seasonal influenza in South Korea.
Design: This nationwide, population-based cohort study utilized the National Health Insurance claim database, including individuals newly diagnosed with COVID-19 or influenza between July 2022 and December 2023. The primary outcome was 30-day all-cause mortality. Logistic regression analysis was conducted to compare mortality risks, adjusting for demographic and clinical covariates.
Results: A total of 12,802,169 patients with COVID-19 and 2,888,777 patients with influenza were analyzed. COVID-19 was associated with significantly higher 30-day all-cause mortality compared with influenza (adjusted odds ratio [aOR], 1.76; 95% CI, 1.60-1.94). This elevated risk remained consistent across most subgroups defined by age, sex, healthcare utilization, and comorbidities. Particularly higher risks were observed among adults aged 18-64 years (aOR, 2.93), hospitalized patients (aOR, 2.55), and those with myocardial infarction (aOR, 2.24).
Conclusions: COVID-19 is associated with markedly higher short-term mortality than influenza across diverse clinical and demographic subgroups. These findings underscore the ongoing need for vigilant prevention efforts, and vaccination. This study represents the first large-scale nationwide analysis, and the first in Asia, conducted in the post-COVID-19 era.
Keywords: 30-day mortality; COVID-19; Health Insurance Claims Data; influenza.