tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Mar 16;S1201-9712(21)00262-9.
doi: 10.1016/j.ijid.2021.03.044. Online ahead of print.
Impact of the coronavirus 2019 (COVID-19) on vasooclusive crisis in patients with sickle cell anaemia
S Alkindi[SUP] 1 [/SUP], R A Elsadek[SUP] 2 [/SUP], A Al-Madhani[SUP] 3 [/SUP], M Al-Musalhi[SUP] 4 [/SUP], S Y AlKindi[SUP] 5 [/SUP], G Al-Khadouri[SUP] 6 [/SUP], B Al Rawahi[SUP] 6 [/SUP], S Al-Ruqeishi[SUP] 6 [/SUP], J Al-Yazeedi[SUP] 7 [/SUP], Y A Wali[SUP] 8 [/SUP], S Al Shamakhi[SUP] 9 [/SUP], M Al Rawahi[SUP] 10 [/SUP], A V Pathare[SUP] 11 [/SUP]
Affiliations
Abstract
Objectives: The aim of this study was to assess the impact of COVID-19 on the morbidity and mortality on vasooclusive crisis (VOC) in sickle cell anaemia (SCA) patients.
Methods: One hundred patients with(fifty) or without COVID-19 PCR positivity(fifty), were enrolled in a prospective cohort study after signing a written informed consent.
Results: The COVID-19 positive patients had significantly higher median VOC episodes/year i.e 3 /year (IQR, 1-6 /year) v/s 2 /year (IQR, 2-12 /year) (p < 0.05) respectively, however the need for hospitalization was similar. There was a higher culture proven infection in COVID-19 negative group (P = 0.05). COVID-19 positive group had more osteonecrosis (p < 0.05), splenic sequestration, splenomegaly, and hepatic crisis (P values 0.05, 0.006 and 0.02 respectively). Symptoms of fever, cough, fatigue, abdominal pain and anosmia were significantly higher (p < 0.05) in the COVID-19 positive patients. Both cohorts, showed a fall in the mean haemoglobin, lymphocyte subset, platelets, and reticulocytes, whereas, the LDH and ferritin were significantly elevated. In SCA COVID-19 positive patients the rise in WBC, reticulocyte%, platelets, and ferritin was subdued (p < 0.05). Two died in COVID-19 positive, whereas three died in the COVID-19 negative, without statistically significant difference in mortality.
Conclusions: Although COVID-19 infection may have triggered the onset of VOC, it did not significantly influence the morbidity or mortality in this SCA cohort.
Keywords: COVID-19; Coronavirus; SCA; Sickle cell anaemia; Vasooclusive crises.
. 2021 Mar 16;S1201-9712(21)00262-9.
doi: 10.1016/j.ijid.2021.03.044. Online ahead of print.
Impact of the coronavirus 2019 (COVID-19) on vasooclusive crisis in patients with sickle cell anaemia
S Alkindi[SUP] 1 [/SUP], R A Elsadek[SUP] 2 [/SUP], A Al-Madhani[SUP] 3 [/SUP], M Al-Musalhi[SUP] 4 [/SUP], S Y AlKindi[SUP] 5 [/SUP], G Al-Khadouri[SUP] 6 [/SUP], B Al Rawahi[SUP] 6 [/SUP], S Al-Ruqeishi[SUP] 6 [/SUP], J Al-Yazeedi[SUP] 7 [/SUP], Y A Wali[SUP] 8 [/SUP], S Al Shamakhi[SUP] 9 [/SUP], M Al Rawahi[SUP] 10 [/SUP], A V Pathare[SUP] 11 [/SUP]
Affiliations
- PMID: 33741487
- DOI: 10.1016/j.ijid.2021.03.044
Abstract
Objectives: The aim of this study was to assess the impact of COVID-19 on the morbidity and mortality on vasooclusive crisis (VOC) in sickle cell anaemia (SCA) patients.
Methods: One hundred patients with(fifty) or without COVID-19 PCR positivity(fifty), were enrolled in a prospective cohort study after signing a written informed consent.
Results: The COVID-19 positive patients had significantly higher median VOC episodes/year i.e 3 /year (IQR, 1-6 /year) v/s 2 /year (IQR, 2-12 /year) (p < 0.05) respectively, however the need for hospitalization was similar. There was a higher culture proven infection in COVID-19 negative group (P = 0.05). COVID-19 positive group had more osteonecrosis (p < 0.05), splenic sequestration, splenomegaly, and hepatic crisis (P values 0.05, 0.006 and 0.02 respectively). Symptoms of fever, cough, fatigue, abdominal pain and anosmia were significantly higher (p < 0.05) in the COVID-19 positive patients. Both cohorts, showed a fall in the mean haemoglobin, lymphocyte subset, platelets, and reticulocytes, whereas, the LDH and ferritin were significantly elevated. In SCA COVID-19 positive patients the rise in WBC, reticulocyte%, platelets, and ferritin was subdued (p < 0.05). Two died in COVID-19 positive, whereas three died in the COVID-19 negative, without statistically significant difference in mortality.
Conclusions: Although COVID-19 infection may have triggered the onset of VOC, it did not significantly influence the morbidity or mortality in this SCA cohort.
Keywords: COVID-19; Coronavirus; SCA; Sickle cell anaemia; Vasooclusive crises.