tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Jul 4;S1201-9712(20)30545-2.
doi: 10.1016/j.ijid.2020.07.003. Online ahead of print.
Dynamic Changes of Peripheral Blood Lymphocytes Subsets in Adult Patients With COVID-19
Zhifeng Deng[SUP] 1 [/SUP], Minli Zhang[SUP] 2 [/SUP], Ting Zhu[SUP] 1 [/SUP], Zhili Liu[SUP] 3 [/SUP], Zheming Liu[SUP] 4 [/SUP], Rong Xiang[SUP] 1 [/SUP], Wei Zhang[SUP] 1 [/SUP], Yu Xu[SUP] 5 [/SUP]
Affiliations
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the dynamic changes of peripheral blood lymphocytes subsets in adult patients with COVID-19.
Methods: Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 435 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and retrospectively analyzed. The counts of lymphocyte subsets at each week after the onset of the illness were compared with other weeks of illness and with those from normal individuals.
Results: The various lymphocyte subsets (CD3 +, CD4 +, CD8 +, CD19 +and CD16/56 +) were below the normal ranges at the first week after the onset of the illness, reaching a nadir during the second week, which increased gradually in the third week and returned to normal levels in the fifth week, but was still lower than the healthy controls. The CD3+, CD4+ and CD8+ counts were significantly lower in those with severe disease compared to those with non-severe disease, and in those patients that died compared to those who recovered.
Discussion: our research indicates that the levels of peripheral blood lymphocyte subsets (CD3 +, CD4 +, and CD8 +) are associated with disease progression, severity, and prognosis in patients with COVID-19. Dynamic monitoring of human immune function is one of the indicators for evaluating the severity and prognosis of COVID-19 patients, and it is helpful to formulate appropriate treatment strategies.
Keywords: COVID-19; cellular immunity; lymphocytes subsets; prognosis; severity.
. 2020 Jul 4;S1201-9712(20)30545-2.
doi: 10.1016/j.ijid.2020.07.003. Online ahead of print.
Dynamic Changes of Peripheral Blood Lymphocytes Subsets in Adult Patients With COVID-19
Zhifeng Deng[SUP] 1 [/SUP], Minli Zhang[SUP] 2 [/SUP], Ting Zhu[SUP] 1 [/SUP], Zhili Liu[SUP] 3 [/SUP], Zheming Liu[SUP] 4 [/SUP], Rong Xiang[SUP] 1 [/SUP], Wei Zhang[SUP] 1 [/SUP], Yu Xu[SUP] 5 [/SUP]
Affiliations
- PMID: 32634585
- DOI: 10.1016/j.ijid.2020.07.003
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the dynamic changes of peripheral blood lymphocytes subsets in adult patients with COVID-19.
Methods: Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 435 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and retrospectively analyzed. The counts of lymphocyte subsets at each week after the onset of the illness were compared with other weeks of illness and with those from normal individuals.
Results: The various lymphocyte subsets (CD3 +, CD4 +, CD8 +, CD19 +and CD16/56 +) were below the normal ranges at the first week after the onset of the illness, reaching a nadir during the second week, which increased gradually in the third week and returned to normal levels in the fifth week, but was still lower than the healthy controls. The CD3+, CD4+ and CD8+ counts were significantly lower in those with severe disease compared to those with non-severe disease, and in those patients that died compared to those who recovered.
Discussion: our research indicates that the levels of peripheral blood lymphocyte subsets (CD3 +, CD4 +, and CD8 +) are associated with disease progression, severity, and prognosis in patients with COVID-19. Dynamic monitoring of human immune function is one of the indicators for evaluating the severity and prognosis of COVID-19 patients, and it is helpful to formulate appropriate treatment strategies.
Keywords: COVID-19; cellular immunity; lymphocytes subsets; prognosis; severity.